The NOD: a signaling module that regulates apoptosis and host defense against pathogens

Oncogene
Naohiro Inohara, Gabriel Núñez

Abstract

Nods, a growing family of proteins containing a nucleotide-binding oligomerization domain (NOD), are involved in the regulation of programmed cell death (PCD) and immune responses. Members of the family include Apaf-1, Ced-4, Nod1, Nod2, and the cytosolic products of plant disease resistance genes. The NOD module is homologous to the ATP-binding cassette (ABC) found in a large number of proteins with diverse biological function. The centrally located NOD promotes activation of effector molecules through self-association and induced proximity of binding partners. The C-terminal domain of Nods serves as a sensor for intracellular ligands, whereas the N-terminal domain mediates binding to dowstream effector molecules and activation of diverse signaling pathways. Thus, Nods activate, through the NOD module, diverse signaling pathways involved in the elimination of cells via PCD and the host defense against pathogens.

References

Jun 28, 1969·Lancet
Aug 1, 1982·Biochemical Society Transactions·J E WalkerM Saraste
Nov 19, 1993·Cell·P C Doherty
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BertinJ I Cohen
Feb 7, 1997·Cell·M D JacobsonM C Raff
Feb 1, 1997·The Journal of Arthroplasty·A A HofmannY Zhang
May 1, 1997·Trends in Biochemical Sciences·K HofmannJ Tschopp
Jul 1, 1997·Current Biology : CB·S Seshagiri, L K Miller
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·B SchrankM Sendtner
Aug 21, 1997·Nature·A M ChinnaiyanV M Dixit
Jan 22, 1998·Current Opinion in Structural Biology·S R Sprang
Feb 28, 1998·The Journal of Biological Chemistry·M MuzioV M Dixit
Apr 16, 1998·The Journal of Biological Chemistry·G PanV M Dixit
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y HuG Núñez
Jun 27, 1998·The Journal of Biological Chemistry·J V McCarthyV M Dixit

❮ Previous
Next ❯

Citations

Jan 9, 2007·Inflammatory Bowel Diseases·Johan Van LimbergenJack Satsangi
Aug 24, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Amlan BiswasKoichi S Kobayashi
Feb 7, 2008·Immunogenetics·Christoph GascheRobert Schwarzenbacher
Nov 11, 2006·Rheumatology International·Tae-Hwan KimRobert D Inman
Aug 10, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kristen H TaylorJames E Womack
Mar 3, 2007·International Journal of Colorectal Disease·E Leshinsky-SilverA Levine
Sep 30, 2009·International Journal of Colorectal Disease·Yun TianChangshan Ren
Feb 9, 2010·Modern Rheumatology·Tetsuo Kubota, Ryuji Koike
Jan 24, 2004·Microbes and Infection·Maëlle MolmeretYousef Abu Kwaik
Apr 2, 2003·Trends in Cell Biology·Harri A JärveläinenArturo Zychlinsky
Feb 9, 2002·Current Opinion in Microbiology·Naohiro InoharaGabriel Nuñez
May 4, 2010·Cellular & Molecular Immunology·Chaofeng HuSuisheng Tang
Apr 15, 2005·Nature·Stefan J RiedlYigong Shi
Dec 22, 2005·Nature Immunology·Jiahuai Han, Richard J Ulevitch
Feb 25, 2006·Nature Reviews. Immunology·Jenny P-Y TingHal M Hoffman
Sep 18, 2010·Nature Reviews. Immunology·Thirumala-Devi Kanneganti
Feb 10, 2012·Molecular Biology and Evolution·Shigeki NakagomeHiroki Oota
Jul 16, 2002·Current Opinion in Rheumatology·César Pacheco-TenaRobert D Inman
Apr 21, 2004·Journal of Pediatric Gastroenterology and Nutrition·Qian Yuan, W Allan Walker
Jul 20, 2002·Inflammatory Bowel Diseases·S J H van Deventer
Jun 1, 2004·Inflammatory Bowel Diseases·G Scott LichtenbergerLena Alexopoulou
Apr 5, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Deniz TekinBusra Isin Kutlubay
Apr 3, 2003·The Plant Cell·Blake C MeyersRichard W Michelmore
Feb 22, 2005·The Plant Cell·Antonious Al-DaoudeMurray Grant
Apr 9, 2010·Clinical Microbiology Reviews·Hayley J NewtonElizabeth L Hartland
Nov 3, 2012·Bone Marrow Research·Neema P MayorSteven G E Marsh
Aug 24, 2010·BMC Systems Biology·David J LynnRobert E W Hancock
Sep 19, 2007·Journal of Leukocyte Biology·Jeanette M WilmanskiKoichi S Kobayashi
Dec 2, 2008·PLoS Pathogens·Atsuko FukazawaHans-Christian Reinecker
Aug 5, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Silvia Mascheretti, Stefan Schreiber
Jun 15, 2013·Beilstein Journal of Organic Chemistry·Paul M HershbergerGregory P Roth
Feb 16, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Michael C Heymann, Angela Rösen-Wolff
Feb 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jules AdeRoger W Innes
May 11, 2002·Current Treatment Options in Gastroenterology·Sander J.H. Van Deventer
Aug 26, 2014·Inflammatory Bowel Diseases·Beckley K DavisIrving C Allen
Oct 19, 2004·European Journal of Gastroenterology & Hepatology·Maria GazouliVassilis Gorgoulis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2021 Meta ULC. All rights reserved