The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

Pain
Flávia V Santa-CecíliaThiago M Cunha

Abstract

Neuropathic pain is one of the most important types of chronic pain. It is caused by neuronal damage. Clinical and experimental studies suggest a critical role for neuroimmune interactions in the development of neuropathic pain. In this article, we have shown that the cytoplasmic receptor Nod-like receptor-2, NOD2, and its adaptor-signaling molecule RIPK2 participate in the development of neuropathic pain after peripheral nerve injury (spared nerve injury model). The activation of NOD2 signaling in peripheral macrophage mediates the development of neuropathic pain through the production of pronociceptive cytokines (tumor necrosis factor and IL-1β). This study found that peripheral nerve injury promoted a systemic increase in the NOD2 ligand. These results highlight a previously undetermined role for NOD2 signaling in the development of neuropathic pain, suggesting a new potential target for preventing neuropathic pain.

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Citations

Nov 21, 2018·The Journal of Experimental Medicine·Zhi-Jun ZhangYong-Jing Gao
Nov 30, 2019·Pain Practice : the Official Journal of World Institute of Pain·Glauce R PigattoNivaldo A Parizotto
Feb 13, 2020·Frontiers in Immunology·Miriam M FonsecaThiago M Cunha
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Valentin J HeimUeli Nachbur
Aug 14, 2020·Technology in Cancer Research & Treatment·Jun ShenShufang Hu
May 14, 2021·Pain Reports·Conceição Elidianne Aníbal SilvaThiago Mattar Cunha
May 28, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kufreobong E InyangGeoffroy Laumet
Sep 9, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joerg ErmannFergus R Byrne

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