The Nogo signaling pathway for regeneration block

Annual Review of Neuroscience
Zhigang He, Vuk Koprivica

Abstract

A hostile environment and decreased regenerative capacity may contribute to the failure of axon regeneration in the adult central nervous system. Recent studies leading to the identification of several myelin-associated inhibitors and their signaling molecules provide opportunitities to assess the contribution of these inhibitory molecules in restricting axon regeneration. These findings may ultimately allow for the development of strategies to alleviate the inhibitory effects of such molecules in an effort to encourage axon regeneration after spinal cord and brain injury.

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Methods Mentioned

BETA
X-ray
size fractionation
transgenic
GTPase
GTPases
nucleotide exchange
two-hybrid

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