The Nomogram Model Predicting Overall Survival and Guiding Clinical Decision in Patients With Glioblastoma Based on the SEER Database

Frontiers in Oncology
Hongjian LiXiao Zhu

Abstract

Background: Patients with glioblastoma have a poor prognosis. We want to develop and validate nomograms for predicting overall survival in patients with glioblastoma. Methods: Data of patients with glioblastoma diagnosed pathologically in the SEER database from 2007 to 2016 were collected by SEER*Stat software. After eliminating invalid and missing clinical information, 3,635 patients (total group) were finally identified and randomly divided into the training group (2,183 cases) and the verification group (1,452 cases). Cox proportional risk regression model was used in the training group, the verification group and the total group to analyze the prognostic factors of patients in the training group, and then the nomogram was constructed. C-indexes and calibration curves were used to evaluate the predictive value of nomogram by internal (training group data) and external validation (verification group data). Results: Cox proportional risk regression model in the training group showed that age, year of diagnosis, laterality, radiation, chemotherapy were all influential factors for prognosis of patients with glioblastoma (P < 0.05) and were all used to construct nomogram as well. The internal and external validation results of no...Continue Reading

References

Mar 17, 2001·JAMA : the Journal of the American Medical Association·R YancikJ W Yates
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fidel-David Huitzil-MelendezGhassan K Abou-Alfa
Jan 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yizhou WangFeng Shen
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Antonio Omuro, Lisa M DeAngelis
Dec 19, 2013·Case Reports in Oncology·Giandomenico RovielloPaolo Tini
Jan 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wenhua LiangJianxing He
Apr 8, 2015·The Lancet Oncology·Vinod P BalachandranRonald P DeMatteo
Jul 22, 2015·Neurocirugía·Cristian de Quintana-SchmidtJoan Molet-Teixidó
Dec 31, 2015·Cancer Medicine·Jingjing ZhuLang Wu
Mar 8, 2016·Handbook of Clinical Neurology·Hans-Georg WirschingMichael Weller
Nov 14, 2016·The Journal of Thoracic and Cardiovascular Surgery·Chenghua JinJian Hu
Mar 16, 2017·The New England Journal of Medicine·James R PerryUNKNOWN Trial Investigators
Jun 24, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian M Alexander, Timothy F Cloughesy
Jan 23, 2018·Journal of Neuro-oncology·Yung-Chiang LiuPin-Yuan Chen
Apr 12, 2019·Frontiers in Pharmacology·Erik LadomerskyDerek A Wainwright
Feb 18, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiangping LiangXiao Zhu
Apr 6, 2020·Stereotactic and Functional Neurosurgery·Gokhan YaprakNecati Tatarlı

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Citations

Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhen LiuYi Qi
Nov 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ZhuHui Luo
Sep 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yujia ZhouXiao Zhu

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Software Mentioned

Excel
R
rcorrp
cens
* Stat
SEER
caret
Hmisc

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