PMID: 2858796Mar 25, 1985

The non-benzodiazepine anxiolytic buspirone inhibits stress-induced renin secretion and lowers heart rate

Life Sciences
L D Van de KarK D Richardson

Abstract

The non benzodiazepine drug, buspirone, produces a dose-dependent biphasic effect on plasma renin activity in non-stressed rats. Low doses (0.1 - 2.0 mg/kg i.p.) decrease while high doses (10.0 - 50.0 mg/kg i.p.) increase plasma renin activity. The maximal decrease in plasma renin activity produced by buspirone (1.0 mg/kg i.p.) was observed 30 minutes post-injection. In addition, buspirone (0.5 and 2.0 mg/kg i.p.) blocked the stress-induced rise in plasma renin activity. This effect of buspirone is in contrast to the previously observed failure of the benzodiazepine anxiolytics to alter the effect of stress on plasma renin activity. Administration of buspirone (0.5 mg/kg i.p.) produced a sustained reduction (15%) in heart rate but did not affect mean arterial pressure. The present data support the view that the mechanism of the anxiolytic action of buspirone is different from that of the benzodiazepines.

References

Feb 14, 1995·European Journal of Pharmacology·A D LevyL D Van de Kar
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·A D LevyL D Van de Kar
Jan 1, 1996·Behavioural Brain Research·L D Van de KarA D Levy
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, L D Van de Kar
Jul 4, 1998·European Journal of Pharmacology·A VicenticL D Van de Kar
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·L D Van de Kar
Dec 23, 2006·Clinical and Experimental Pharmacology & Physiology·Eugene Nalivaiko
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·L D Van de Kar
Jan 12, 1999·Frontiers in Neuroendocrinology·L D Van de Kar, M L Blair

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