The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

Cancers
Eugenio MorelliNicola Amodio

Abstract

Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.

References

Apr 1, 1996·Nucleic Acids Research·C SchindewolfH Domdey
Feb 8, 2003·Trends in Biotechnology·Michael Petersen, Jesper Wengel
Jul 23, 2005·Angewandte Chemie·Fang ZhaoThomas Hermann
Oct 28, 2005·Genes, Chromosomes & Cancer·Wayne Tam, James E Dahlberg
Dec 13, 2006·Nature Biotechnology·Kenneth F Blount, Ronald R Breaker
Mar 31, 2007·Developmental Cell·Michelle A CarmellGregory J Hannon
Aug 4, 2007·British Journal of Haematology·Rafael Fonseca, Suzanne Hayman
Sep 12, 2007·Journal of the American Chemical Society·Pravin S ShirudeShankar Balasubramanian
Dec 7, 2007·Mechanisms of Ageing and Development·Kathleen Collins
Dec 11, 2007·Nature Genetics·Tsung-Cheng ChangJoshua T Mendell
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 21, 2008·Angewandte Chemie·Kiranmai GumireddyAlexander Deiters
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Flavia PichiorriCarlo M Croce
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Apr 22, 2009·Expert Opinion on Drug Metabolism & Toxicology·Richard S Geary
Apr 28, 2009·Genes, Chromosomes & Cancer·Laura ChiecchioUNKNOWN UK Myeloma Forum
Apr 30, 2009·Blood·Aldo M RoccaroIrene M Ghobrial
May 19, 2009·Current Opinion in Cell Biology·Christopher A Brosnan, Olivier Voinnet
Aug 25, 2009·Journal of Molecular Recognition : JMR·Jiro Kondo, Eric Westhof
Jun 23, 2010·Journal of the American Chemical Society·Gavin W CollieValérie Gabelica
Jul 10, 2010·Nucleic Acids Research·Kai WangDavid J Galas
Aug 18, 2010·Mayo Clinic Proceedings·Rishi K Wadhera, S Vincent Rajkumar
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jason D ArroyoMuneesh Tewari
Mar 24, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Phong TrangFrank J Slack
May 28, 2011·Accounts of Chemical Research·Katherine E Deigan, Adrian R Ferré-D'Amaré
Jun 1, 2011·Human Genetics·Daphne B Pontier, Joost Gribnau
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Jun 29, 2011·British Journal of Haematology·Kwan-Yeung WongChor-Sang Chim
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Aug 13, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Liangping WengDavid C Seldin
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang

❮ Previous
Next ❯

Citations

Sep 13, 2020·Non-coding RNA·Lavinia RaimondiNicola Amodio
Jun 17, 2020·Therapeutic Advances in Medical Oncology·Yidi QuDi Wang
Jul 25, 2020·Haematologica·Annamaria Gulla, Kenneth C Anderson
Oct 16, 2020·Haematologica·Annamaria Gulla, Kenneth C Anderson
Jul 3, 2021·International Journal of Molecular Sciences·Shiva Kumar Reddy Mukkamalla, Dhatri Malipeddi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
antisense oligonucleotides
X-ray
acetylation
histone acetylation
xenograft
RNA-seq
ISS
chromosomal aberrations

Software Mentioned

Inforna

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Genetics : TIG
Junjie T HuaHousheng H He
Cancer Treatment and Research
Carla S Wilson
Advances in Immunology
N NishimotoT Kishimoto
JAMA : the Journal of the American Medical Association
B BarlogieS Jagannath
© 2021 Meta ULC. All rights reserved