The Non-coding Side of Medulloblastoma

Frontiers in Cell and Developmental Biology
Pietro Laneve, Elisa Caffarelli

Abstract

Medulloblastoma (MB) is the most common pediatric brain tumor and a primary cause of cancer-related death in children. Until a few years ago, only clinical and histological features were exploited for MB pathological classification and outcome prognosis. In the past decade, the advancement of high-throughput molecular analyses that integrate genetic, epigenetic, and expression data, together with the availability of increasing wealth of patient samples, revealed the existence of four molecularly distinct MB subgroups. Their further classification into 12 subtypes not only reduced the well-characterized intertumoral heterogeneity, but also provided new opportunities for the design of targets for precision oncology. Moreover, the identification of tumorigenic and self-renewing subpopulations of cancer stem cells in MB has increased our knowledge of its biology. Despite these advancements, the origin of MB is still debated, and its molecular bases are poorly characterized. A major goal in the field is to identify the key genes that drive tumor growth and the mechanisms through which they are able to promote tumorigenesis. So far, only protein-coding genes acting as oncogenic drivers have been characterized in each MB subgroup. The...Continue Reading

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E ShtivelmanJ M Bishop
Oct 1, 1973·Cancer·M N Hart, K M Earle
Jan 10, 1980·Nature·M R LernerJ A Steitz
Oct 21, 1993·Nature·Y HaoB Tycko
Apr 22, 1993·Nature·S RainierA P Feinberg
Jul 1, 1996·Journal of Neuro-oncology·J T Rutka, H J Hoffman
Dec 1, 1996·Journal of Neuropathology and Experimental Neurology·S AlbrechtT Pietsch
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A GrotzerJ Q Trojanowski
Mar 8, 2000·Mechanisms of Development·T KatahiraH Nakamura
Apr 10, 2002·Archives of Neurology·Lara J Kunschner
Jun 5, 2002·Nature Reviews. Cancer·Ariel Ruiz i AltabaNadia Dahmane
Jun 18, 2002·Nature Genetics·Michael D TaylorDavid Hogg
Jun 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Trudy G OliverRobert J Wechsler-Reya
Feb 19, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amar GajjarRichard J Gilbertson
Sep 2, 2004·Molecular and Cellular Biology·Xiaohua SuSadhan Majumder
Nov 3, 2004·Cancer Research·Xing FanCharles G Eberhart
Dec 22, 2004·The Journal of Biological Chemistry·Georg RosenbergerKerstin Kutsche
Jan 15, 2005·Trends in Molecular Medicine·Silvia Marino
Apr 5, 2005·Oncogene·Hiromichi KimuraTom Curran
Apr 23, 2005·The European Journal of Neuroscience·Lena SmirnovaF Gregory Wulczyn
Jun 10, 2005·Nature·Lin HeScott M Hammond
Jun 10, 2005·Nature·Kathryn A O'DonnellJoshua T Mendell
Jul 19, 2005·Cancer Research·Jennifer A ChanKenneth S Kosik
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frank MendrzykPeter Lichter
Dec 13, 2005·European Journal of Cell Biology·Georg Rosenberger, Kerstin Kutsche
Dec 21, 2005·The Journal of Cell Biology·Hanna Y IrieJoan S Brugge
Jan 18, 2006·Cell Cycle·Martha J Grossel, Philip W Hinds
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cecilia ConacoGail Mandel
Jun 23, 2006·Nature Reviews. Neuroscience·Narender Ramnani
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie EvangelistaFrederic J de Sauvage
Feb 20, 2007·Annual Review of Physiology·Scott M DeWireSudha K Shenoy
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pietro LaneveElisa Caffarelli
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
Jun 8, 2007·Nature·Lin HeGregory J Hannon
Jun 29, 2007·The Journal of Biological Chemistry·Shunbin XuDavid Valle

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Citations

May 18, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anna Prieto-ColominaVíctor Borrell

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Methods Mentioned

BETA
xenograft
xenografts
proteomic profiling
transfection
RNA-Seq
pull-down
CLIP
ChIP-Seq
PCR

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