The non-ionic dimers: a new class of contrast agents

The British Journal of Radiology
P Dawson, M Howell

Abstract

Non-ionic dimers are a new class of iodinated radiological contrast agents. Some physico-chemical and pharmacological properties of three representative compounds are presented. Non-ionic dimers are iso-osmolar with plasma at all iodine concentrations unless diluted with saline and in terms of chemotoxicity they appear to be closely comparable with the established non-ionic monomeric agents. It is shown that the data lend support to the theory that it is the degree of steric hindrance of the hydrophobic iodine atoms by side-chains which determines this chemotoxicity. Areas in which agents of this type may find applications are indicated.

References

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Mar 1, 1983·Clinical Radiology·P DawsonJ Pitfield
Sep 1, 1983·The British Journal of Radiology·P Dawson, D Edgerton

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Citations

Jul 1, 1987·The British Journal of Radiology·R Fox, P Henson
Jul 1, 1987·The British Journal of Radiology·R C Buchan
Apr 1, 1994·The British Journal of Radiology·P DawsonL Machan
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I Gordon, T M Barratt
Jun 16, 2006·Der Anaesthesist·H PreissH Henkes
Sep 1, 1990·European Journal of Radiology·T Riebel, R Wartner
Mar 1, 1991·Current Problems in Diagnostic Radiology·H O Stolberg, B L McClennan
Mar 1, 1993·The Veterinary Clinics of North America. Small Animal Practice·M Holland
Feb 6, 1999·European Journal of Radiology·S K MorcosJ O Karlsson
Aug 23, 2002·Seminars in Dialysis·Peter Dawson
Jan 1, 1991·Chinese Medical Journal·J L GanH Chen
Nov 4, 2006·Expert Review of Cardiovascular Therapy·Peter A McCullough
Aug 1, 1988·Australasian Radiology·P Dawson
Jan 1, 1995·Acta Radiologica. Supplementum·P JyngeA N Oksendal
Mar 1, 1997·Journal of Applied Physiology·E M BaileP D Paré
Sep 11, 2012·Physical Chemistry Chemical Physics : PCCP·Hongyu ChenJeffrey N Anker
Feb 1, 1994·European Journal of Radiology·S OldroydA M el Nahas

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