PMID: 26769826Jan 16, 2016Paper

The non-neuronal heart's acetylcholine in health and disease

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
B Lewartowski, U Mackiewicz

Abstract

In this review we describe the history of almost one century lasting investigations which eventually provided evidence convincing that cardiac myocytes possess all elements of the system of synthesis, intracellular transport and release of acetylcholine (ACh) independent of parasympathetic cholinergic innervation. The myocytes synthesis and release of ACh is tightly connected with their contractile activity. Moreover, it is necessary for maintaining the balance of autonomic control of the heart, particularly important in the heart failure. It has an antyhypertrophic activity and protects myocardium against ischemic/reperfusion injury which shows that it is involved in the regulation of the important cellular signaling pathways. These properties of the non-neuronal ACh system of the heart also rise the hope that it might be used for the therapeutic measures.

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Related Papers

Archivos de la Fundación Roux-Ocefa
C R Pérez Barquet
Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi
Yoshihiko Kakinuma
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Ashbeel RoyMarco A M Prado
Heart Rhythm : the Official Journal of the Heart Rhythm Society
James Martins
© 2022 Meta ULC. All rights reserved