The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury

The Tohoku Journal of Experimental Medicine
Tomofumi HoshinoAkira Hara

Abstract

Acoustic injury is a common cause of hearing loss for people in industrial societies. Cyclooxygenase (COX) and lipoxygenase (LOX) are two important enzymes involved in arachidonic acid metabolism. Two COX isozymes are characterized, COX-1 and COX-2, that differ in terms of regulatory mechanisms of expression. Although COX-1, COX-2, and LOX are expressed in cochlea, their roles played in cochlear acoustic injury have not fully been evaluated. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit either COX or LOX, or both. This study evaluated the effects of NSAIDs on the functional recovery of the cochlea after acoustic injury. Mice were exposed to a 4-kHz pure tone of 128 dB SPL (sound pressure level) for 4 hours and received one of the following drugs for two weeks after acoustic overexposure: indomethacin (COX-1 inhibitor), meloxicam, SC58125, and CAY10404 (COX-2 inhibitors), and nordihydroguaiaretic acid (LOX inhibitor). The hearing ability was evaluated using an auditory brainstem response (ABR) before and after overexposure. The ABR threshold shifts, defined as subtraction between ABR thresholds before and after overexposure, were compared among the control and the medication groups at one and two weeks after acoustic ov...Continue Reading

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Citations

Sep 3, 2010·Journal of Occupational Medicine and Toxicology·Sharon TamirHaim Sohmer
Apr 29, 2009·The Tohoku Journal of Experimental Medicine·Isao UemaetomariAkira Hara
Sep 11, 2014·Advances in Wound Care·Dmitri GourevitchEllen Heber-Katz
Feb 18, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Muhammed Sedat SakatSami Bercin
Oct 25, 2011·Biochemical and Biophysical Research Communications·Tomofumi HoshinoAkira Hara
Feb 8, 2011·Hearing Research·Takayuki Nakagawa
Sep 3, 2013·Geriatrics & Gerontology International·Qingwei RuanZhuowei Yu
Apr 27, 2010·Pharmaceuticals·Tomofumi HoshinoAkira Hara
Jul 5, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Leyla KansuImer Okar
Jul 2, 2009·Current Opinion in Allergy and Clinical Immunology

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