The non-uniform distribution of albumin in human and bovine cornea

Experimental Eye Research
H GongThomas F Freddo

Abstract

In our previous studies, we noted a non-uniform distribution of protein tracer preferentially entering the anterior stromal lamellae of the cornea from the limbus. Given other differences reported previously between the anterior and posterior lamellae of the cornea, and the number of corneal disorders in which abnormalities are preferentially confined to either the anterior or posterior lamellae, we were prompted to examine the distribution of albumin in normal human and bovine cornea. The distribution of albumin in bovine and human cornea was studied immunohistochemically. Total soluble protein and albumin in the anterior 1/3 and posterior 2/3 of the central, middle and peripheral cornea of bovine eyes was measured biochemically. To aid in interpreting the findings, a theoretical model was developed based upon the combined effects of diffusive and convective transport. Using immunohistochemical methods, in both bovine and human eyes, intense staining of albumin was found in the anterior 1/3 of the corneal stroma. There was a gradual reduction in staining intensity from the limbus to the central cornea in the anterior corneal stroma. Less staining was found in the posterior 2/3 of corneal stroma. Additionally, a greater concent...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jul 1, 1979·The Journal of Physiology·S D Klyce, S R Russell
Jul 1, 1975·American Journal of Ophthalmology·M R Allansmith, B H McClellan
Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Levick
Nov 1, 1971·Experimental Eye Research·J H KimD Paton
Dec 1, 1965·Experimental Eye Research·D M Maurice, P G Watson
Jan 1, 1981·Current Eye Research·D Lee, G Wilson
Mar 1, 1996·Microscopy Research and Technique·R W Beuerman, L Pedroza

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Citations

Sep 26, 2003·The British Journal of Ophthalmology·S ShimmuraK Tsubota
Jul 11, 2013·The Ocular Surface·Gunilla RunströmBrian Tighe
Sep 12, 2009·Acta histochemica·Shamim MushtaqNikhat Ahmed
Nov 29, 2012·Experimental Eye Research·Thomas F FreddoHaiyan Gong
Apr 4, 2008·American Journal of Physiology. Cell Physiology·William M DismukeDorette Z Ellis
Nov 24, 2005·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Michael J Doughty

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