The noncoding-RNA landscape in cardiovascular health and disease

Non-coding RNA Research
Vittoria Di MauroDaniele Catalucci

Abstract

The cardiovascular system plays a pivotal role in regulating and maintaining homeostasis in the human body. Therefore any alteration in regulatory networks that orchestrate heart development as well as adaptation to physiological and environmental stress might result in pathological conditions, which represent the leading cause of death worldwide [1]. The latest advances in genome-wide techniques challenged the "protein-central dogma" with the discovery of the so-called non-coding RNAs (ncRNAs). Despite their lack of protein coding potential, ncRNAs have been largely demonstrated to regulate the majority of biological processes and have also been largely implicated in cardiovascular disorders. This review will first discuss the important mechanistic aspects of some of the classes of ncRNAs such as biogenesis, mechanism of action, as well as their involvement in cardiac diseases. The ncRNA potential uses as therapeutic molecules, with a specific focus on the latest technologies for their in vivo delivery as drug targets, will be described.

Citations

Dec 14, 2018·Cells·Miruna Mihaela MicheuMaria Dorobantu
May 14, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexander T Mikhailov, Mario Torrado
Feb 7, 2019·Cancer Gene Therapy·Xiaotong ZhangChuize Kong
May 1, 2020·European Heart Journal·Ulf LandmesserThomas F Lüscher
Apr 9, 2019·Molecular Medicine Reports·Qijun ZhangLingmei Qian

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Methods Mentioned

BETA
antisense oligonucleotides
antisense oligonucleotide
chemical modification
chemical modifications

Related Concepts

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Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

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