The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and Related Family: Mechanistic Insights in Plant Disease Resistance

Frontiers in Plant Science
Robert BackerNoelani van den Berg

Abstract

The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1) and related NPR1-like proteins are a functionally similar, yet surprisingly diverse family of transcription co-factors. Initially, NPR1 in Arabidopsis was identified as a positive regulator of systemic acquired resistance (SAR), paralogs NPR3 and NPR4 were later shown to be negative SAR regulators. The mechanisms involved have been the subject of extensive research and debate over the years, during which time a lot has been uncovered. The known roles of this protein family have extended to include influences over a broad range of systems including circadian rhythm, endoplasmic reticulum (ER) resident proteins and the development of lateral organs. Recently, important advances have been made in understanding the regulatory relationship between members of the NPR1-like protein family, providing new insight regarding their interactions, both with each other and other defense-related proteins. Most importantly the influence of salicylic acid (SA) on these interactions has become clearer with NPR1, NPR3, and NPR4 being considered bone fide SA receptors. Additionally, post-translational modification of NPR1 has garnered attention during the past years, adding to the growing regu...Continue Reading

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Citations

Oct 22, 2019·Frontiers in Plant Science·Yi-Chang SungJen-Chih Chen
Aug 13, 2020·International Journal of Molecular Sciences·Ali MuhammadLingqiang Wang
Oct 13, 2020·Frontiers in Plant Science·Lei-Ming SunJin-Yong Chen
Dec 2, 2020·International Journal of Molecular Sciences·Wanlong SuWeilun Yin
Sep 6, 2020·Cell·Tanja Mittag, Lucia C Strader
Dec 22, 2020·Critical Reviews in Plant Sciences·Pai LiBrad Day
Dec 31, 2020·International Journal of Molecular Sciences·Lisa DavidSixue Chen
Aug 24, 2020·Pesticide Biochemistry and Physiology·Lin CaiXianchao Sun
Mar 8, 2021·Biochemical and Biophysical Research Communications·Seungmin SonSang Ryeol Park
Mar 23, 2021·Frontiers in Plant Science·Noëlani van den BergS Ashok Prabhu
Jun 3, 2021·International Journal of Molecular Sciences·Kalaivani NadarajahNur Sabrina Natasha Abdul Rahman
Oct 2, 2021·Plant Physiology·Theoni MargaritopoulouEmilia Markellou

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Methods Mentioned

BETA
transgenic
equilibrium dialysis
co-immunoprecipitation
protein folding
acetylation
sumoylation
nuclear translocation

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