PMID: 7539997Jan 1, 1995Paper

The nonribosomal peptide biosynthetic system--on the origins of structural diversity of peptides, cyclopeptides and related compounds

Antonie van Leeuwenhoek
H Kleinkauf, H von Döhren

Abstract

A variety of peptides have been detected in microorganisms. Some have found applications in various fields, for example the classical beta-lactam antibiotics, immunosuppressors like cyclosporin, promising new antibacterials like teichoplanin or daptomycin and antifungals like echinocandin. For none of these has it been established how their complicated biosynthetic pathways have evolved or what functions they fulfill within or for their producers. So it is unclear what selection processes limit the range of their structural analogues within various groups of microorganisms. We here consider recent data in the field of biosynthesis and how they may suggest mechanisms of genetic diversity. These may illustrate the complexity of genetic and intracellular organization of biosynthetic pathways and indicate the cellular context of some metabolites related to the complex background of the production of each metabolite. Research focusing on various targets like the increase of productivity of fermentations or the spread of resistances to antibacterials is slowly being understood.

References

Jan 1, 1992·Annual Review of Microbiology·Y AharonowitzJ F Martin
Dec 1, 1992·Trends in Biochemical Sciences·M W SmithR F Doolittle
Apr 22, 1992·Biochimica Et Biophysica Acta·W H MüllerA J Verkleij
Apr 1, 1992·Die Naturwissenschaften·H KleinkaufH von Döhren
Jun 15, 1992·Gene·R A MaplestoneD H Williams
Jan 1, 1990·Annual Review of Genetics·D A Hopwood, D H Sherman
Aug 1, 1990·FEBS Letters·H Kleinkauf, H von Döhren
Aug 28, 1990·European Journal of Biochemistry·H Kleinkauf, H von Döhren
Jan 1, 1990·Annual Review of Microbiology·L C Vining
Sep 1, 1987·The Biochemical Journal·J A CoxM Comte
Jan 1, 1989·Annual Review of Microbiology·E Cundliffe
Nov 1, 1989·Journal of Natural Products·D H WilliamsS K Rahman
Mar 1, 1988·The Journal of Antibiotics·H PeetersH Kleinkauf
Oct 17, 1972·European Journal of Biochemistry·H SaxholmS G Laland
Jan 1, 1983·Annual Review of Biochemistry·S J WakilV C Joshi
May 1, 1983·Journal of General Microbiology·J M Piret, A L Demain
Aug 30, 1983·Biochemistry·E M Krauss, S I Chan
Jan 3, 1984·Biochemistry·E M Krauss, S I Chan
Mar 1, 1993·Molecular Microbiology·M A MarahielP Zuber

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Citations

Nov 10, 2010·Natural Product Reports·Haoran ZhangBlaine A Pfeifer
Nov 9, 2016·Frontiers in Pharmacology·Shivankar AgrawalSunil K Deshmukh
Mar 1, 1996·European Journal of Biochemistry·H Kleinkauf, H Von Döhren
Mar 20, 2010·Canadian Journal of Microbiology·Sonia ChehimiFérid Limam
Jul 3, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Yibing WangChen Wang
Feb 20, 2002·Chemical Reviews·Hans von DöhrenRainer Zocher

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