The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis

European Journal of Pharmacology
H KawaharaBen H C Westerink

Abstract

Multi-probe microdialysis was used to investigate the interaction between the release of noradrenaline and dopamine in the medial prefrontal cortex. Retrograde microdialysis was used to stimulate or inhibit the activity of the locus coeruleus for a restricted period of time, and the response of extracellular noradrenaline and dopamine in the ipsilateral and contralateral medial prefrontal cortex was recorded with microdialysis probes. Infusion of clonidine into the locus coeruleus (100 microM for 45 min) suppressed noradrenaline release and slightly inhibited dopamine release in the ipsilateral medial prefrontal cortex. Application of carbachol to the locus coeruleus (100 microM for 45 min) stimulated both the noradrenaline and dopamine release in the ipsilateral medial prefrontal cortex. No changes were seen in the contralateral medial prefrontal cortex. In the ipsilateral nucleus accumbens, extracellular noradrenaline levels increased, but dopamine levels remained unchanged. Application to the locus coeruleus (during 10 min) of the glutamate receptor agonists N-methyl-D-aspartate (NMDA) (300 microM) or kainate (100 microM) strongly increased extracellular noradrenaline and dopamine levels in the ipsilateral medial prefrontal ...Continue Reading

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Citations

Feb 21, 2009·Neurochemical Research·Tommaso CassanoGabriella Gobbi
Feb 6, 2004·European Journal of Pharmacology·Yukie KawaharaBen H C Westerink
Nov 6, 2003·Neuroscience and Biobehavioral Reviews·Christian A Heidbreder, Henk J Groenewegen
Mar 24, 2005·Progress in Neurobiology·Peter J MorganeDavid J Mokler
Jun 18, 2002·European Journal of Pharmacology·Olga L PudovkinaBen H C Westerink
Aug 23, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J Minzenberg, Cameron S Carter
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark E BardgettMolly S Griffith
Jul 12, 2002·Psychiatry and Clinical Neurosciences·Claude Gottesmann
Jun 26, 2002·The European Journal of Neuroscience·Jouni A Ihalainen, Heikki Tanila
May 4, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Robert W Greene
Dec 30, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Matthijs G P FeenstraDamiaan Denys
Nov 16, 2006·Annals of the New York Academy of Sciences·J G OrtizC A Jiménez-Rivera
Apr 22, 2010·CNS Neuroscience & Therapeutics·Mostafa El MansariPierre Blier
Apr 8, 2015·Pharmacology, Biochemistry, and Behavior·Anahita Torkaman-BoutorabiMohammad-Reza Zarrindast
Jul 6, 2015·European Journal of Pharmacology·Tomoyuki IjiroHitoshi Ishibashi
Aug 13, 2010·The International Journal of Neuropsychopharmacology·Mercè MasanaFrancesc Artigas
Feb 28, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A I LandaP A Gargiulo
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laurent P LacroixChristian A Heidbreder
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·François Georges, Gary Aston-Jones
Jan 24, 2006·Anesthesia and Analgesia·Robert A Whittington, László Virág
Jan 7, 2003·Journal of Applied Physiology·Musa A HaxhiuV John Massari
Feb 11, 2020·Frontiers in Molecular Neuroscience·Yadollah Ranjbar-Slamloo, Zeinab Fazlali

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