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The noradrenergic neurotoxins DSP4 and xylamine bind to opiate receptors

Brain Research Bulletin

May 1, 1985

Matthew B WilkinsonDella A Wilkinson

PMID: 2992718

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Abstract

DSP4 and xylamine compete with [3H]-naloxone for opiate binding sites with IC50 values of approximately 1 microM. This effect can be blocked by excess naloxone but not by the noradrenaline uptake inhibitors cocaine or desipramine. Other drugs containing the 2-chloroalkylamine structure-...read more

Mentioned in this Paper

Opioid Receptor
Metazoa
Phenylmethylamine
Insula of Reil
Amines
Xylamine
Nitrogen Mustard Compounds
DSP 4 hydrochloride
In Vitro [Publication Type]
Cocaine Hydrochloride
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The noradrenergic neurotoxins DSP4 and xylamine bind to opiate receptors

Brain Research Bulletin

May 1, 1985

Matthew B WilkinsonDella A Wilkinson

PMID: 2992718

DOI:

Abstract

DSP4 and xylamine compete with [3H]-naloxone for opiate binding sites with IC50 values of approximately 1 microM. This effect can be blocked by excess naloxone but not by the noradrenaline uptake inhibitors cocaine or desipramine. Other drugs containing the 2-chloroalkylamine structure-...read more

Mentioned in this Paper

Opioid Receptor
Metazoa
Phenylmethylamine
Insula of Reil
Amines

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