The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Child and Adolescent Psychiatry and Mental Health
Per Hove ThomsenTord Ivarsson

Abstract

This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertraline treatment gives the best outcome; to identify treatment refractory patients and to investigate the outcome of aripiprazole augmentation; to study the outcome over a three year period for each responder including the risk of relapse, and finally to study predictors, moderators and mediators of treatment response. Step 1 was an open and uncontrolled clinical trial with CBT, step 2 was a controlled, randomised non-blinded study of CBT non-responders from step 1. Patients were randomized to receive either sertraline plus CBT-support or continued and modified CBT. In step 3 patients who did not respond to either CBT or sertraline were treated with aripiprazole augmentation to sertraline. This multicenter trial covering three Scandinavian countries is going to be the largest CBT-study for paediatric OCD to date. It is not funded by industry and tries in the short and long-term to answer the question whether further CBT or SSRI is bet...Continue Reading

Citations

Aug 26, 2014·The Psychiatric Clinics of North America·Adam B LewinEric A Storch
Feb 28, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Nor Christian TorpTord Ivarsson
Nov 2, 2014·Health and Quality of Life Outcomes·Bernhard WeidlePer Hove Thomsen
Sep 9, 2015·Journal of Child and Adolescent Psychopharmacology·Gudmundur SkarphedinssonTord Ivarsson
Dec 21, 2014·European Child & Adolescent Psychiatry·Bernhard WeidleThomas Jozefiak
Jan 16, 2015·Journal of Anxiety Disorders·Tord Ivarsson, Gudmundur Skarphedinsson
Nov 1, 2015·European Child & Adolescent Psychiatry·Trine Wigh ArildskovKatja A Hybel
Oct 8, 2016·Journal of Clinical Psychology·Bernhard Weidle, Gudmundur Skarphedinsson
Nov 14, 2016·Journal of Abnormal Child Psychology·Katja Anna HybelPer Hove Thomsen
Jul 1, 2016·European Child & Adolescent Psychiatry·Anna VilladsenCharlotte U Rask
Dec 30, 2016·European Child & Adolescent Psychiatry·Davíð R M A HøjgaardPer Hove Thomsen
Nov 19, 2019·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Sanne JensenPer Hove Thomsen
Apr 17, 2021·European Child & Adolescent Psychiatry·Charlotte Steen DuholmCharlotte Ulrikka Rask
Apr 22, 2021·European Child & Adolescent Psychiatry·Sanne JensenPer Hove Thomsen

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Methods Mentioned

BETA
cognitive behavioural therapy
pharmacotherapy
pharmacotherapists

Software Mentioned

SADS
IVEware for
BOCS
PL
SAS
NordLOTS
CY
SAS combchi

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