The Nordic Trueness Project 2002: use of reference measurement procedure values in a general clinical chemistry survey

Scandinavian Journal of Clinical and Laboratory Investigation
M M PedersenU-R Nordberg

Abstract

Up to 136 laboratories participated in a joint effort to assess the trueness of routine measurements for 14 serum components. An unmodified, fresh-frozen human serum ("IMEP-17 Material 1"), produced for an international inter-laboratory comparison, served as the "master material". The serum had assigned values of the highest available metrological quality, and is assumed to involve no or negligible commutability problems. The material was used in the assignment of traceable values to two other reference sera, "CAL" and "X", through parallel measurements on the three materials according to a common protocol. In this transfer process, uncertainty estimates were provided for all values. The material CAL had been supplied with reference measurement procedure values in 1997, and the two sets of assigned values agreed well. A lyophilized control serum "HK02" was also included in the routine analysis series. It, too, had assigned values based on reference measurement procedures. Significant matrix effects were found. The project has provided: Assigned traceable values for 14 components in a fresh-frozen serum, available to Nordic laboratories for the coming years as "NFKK reference serum X"; Confirmation of earlier assigned reference ...Continue Reading

References

Jun 24, 2003·Scandinavian Journal of Clinical and Laboratory Investigation·L M ThienpontM Budina

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Citations

Apr 30, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Lars Mønster JørgensenGyörgy Sölétormos
Oct 17, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Simon LykkeboePeter Astrup Christensen
Jun 15, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Søren KristiansenSteen Ingemann Hansen
Feb 5, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Abdmajid Osman, Tomas L Lindahl
Apr 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Steen Ingemann HansenGyörgy Sölétormos
Dec 3, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Simon LykkeboePeter Astrup Christensen

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