PMID: 9547329May 23, 1998Paper

The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, Cmu-Cdelta switch, and lambda light chain expression

The Journal of Experimental Medicine
C ArpinY J Liu

Abstract

Human myeloma are incurable hematologic cancers of immunoglobulin-secreting plasma cells in bone marrow. Although malignant plasma cells can be almost eradicated from the patient's bone marrow by chemotherapy, drug-resistant myeloma precursor cells persist in an apparently cryptic compartment. Controversy exists as to whether myeloma precursor cells are hematopoietic stem cells, pre-B cells, germinal center (GC) B cells, circulating memory cells, or plasma blasts. This situation reflects what has been a general problem in cancer research for years: how to compare a tumor with its normal counterpart. Although several studies have demonstrated somatically mutated immunoglobulin variable region genes in multiple myeloma, it is unclear if myeloma cells are derived from GCs or post-GC memory B cells. Immunoglobulin (Ig)D-secreting myeloma have two unique immunoglobulin features, including a biased lambda light chain expression and a Cmu-Cdelta isotype switch. Using surface markers, we have previously isolated a population of surface IgM-IgD+CD38+ GC B cells that carry the most impressive somatic mutation in their IgV genes. Here we show that this population of GC B cells displays the two molecular features of IgD-secreting myeloma c...Continue Reading

References

Jan 1, 1979·Annual Review of Medicine·D E Bergsagel
Sep 1, 1976·The Journal of Experimental Medicine·J W Goding, J E Layton
Mar 1, 1976·European Journal of Immunology·C Stern, I McConnell
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·F RoussetJ Banchereau
Jan 1, 1992·Advances in Oto-rhino-laryngology·P Brandtzaeg, T S Halstensen
Aug 1, 1992·Current Opinion in Oncology·A D Elias
Jul 1, 1990·Molecular and Cellular Biology·M B WhiteP W Tucker
Mar 8, 1990·The New England Journal of Medicine·J EpsteinX Y He
Oct 1, 1973·The Journal of Experimental Medicine·D S RoweB Pernis
Feb 2, 1984·Nature·F R Blattner, P W Tucker
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A C GilliamP W Tucker
Nov 1, 1984·Scandinavian Journal of Haematology·W E Fibbe, J Jansen
Jan 1, 1995·Clinical and Diagnostic Laboratory Immunology·D D BiggsL E Silberstein
Jul 1, 1994·The Journal of Experimental Medicine·V PascualJ D Capra
Nov 1, 1993·The Journal of Experimental Medicine·A C FluckigerJ Banchereau
Apr 1, 1993·The Journal of Experimental Medicine·S L TiegsD Nemazee
Apr 1, 1993·The Journal of Experimental Medicine·D GayM Weigert
Jan 1, 1996·The Journal of Experimental Medicine·P MervilleY J Liu
Mar 1, 1996·The Journal of Experimental Medicine·F MalisanH Martinez-Valdez
Aug 1, 1996·British Journal of Haematology·C KosmasD Loukopoulos
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·E Paramithiotis, M D Cooper
Feb 3, 1997·The Journal of Experimental Medicine·S LebecqueY J Liu
Jan 1, 1965·The Journal of Experimental Medicine·D S ROWE, J L FAHEY

❮ Previous
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Citations

May 25, 2001·International Journal of Hematology·H Kiyoi, T Naoe
Dec 10, 2003·International Journal of Pediatric Otorhinolaryngology·P Brandtzaeg
Aug 4, 2004·Joint, Bone, Spine : Revue Du Rhumatisme·Bouchra AmineNajia Hajjaj-Hassouni
Apr 3, 2001·Molecular Immunology·J L Preud'hommeE Lelièvre
Jun 6, 2000·The Journal of Experimental Medicine·P C WilsonJ D Capra
Feb 9, 2010·International Immunology·Claudia MüllerRalf Küppers
Jul 9, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cécile Toly-NdourPierre Aucouturier
May 29, 2004·Journal of Pediatric Gastroenterology and Nutrition·Per BrandtzaegInger Nina Farstad
May 16, 2006·The American Journal of Surgical Pathology·Sonam PrakashStefania Pittaluga
Dec 3, 1999·Immunological Reviews·P BrandtzaegT Yamanaka
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Per Brandtzaeg
May 19, 2007·The Journal of Clinical Investigation·Kristi KoelschPatrick C Wilson
Jul 20, 2007·Blood·David GonzálezGareth J Morgan
Jul 24, 2007·Blood·Stephen M JacksonJ Donald Capra
Apr 23, 2014·The Journal of Experimental Medicine·Pauline RouaudYves Denizot
Jan 12, 2011·Annual Review of Immunology·Andrea CeruttiAlejo Chorny
Aug 5, 2004·Leukemia & Lymphoma·Jeroen E J GuikemaNicolaas A Bos
Feb 3, 2005·Scandinavian Journal of Immunology·R HadzicA G Wingren
Jul 29, 2005·Immunological Reviews·Per Brandtzaeg, Finn-Eirik Johansen
Nov 21, 2007·British Journal of Haematology·Gerald MartiRobert F Vogt
Dec 19, 2006·Human Immunology·Masahiro TakizawaKazunaga Agematsu
Sep 20, 2005·Developmental and Comparative Immunology·John E ButlerMarek Sinkora
May 24, 2017·International Immunology·William T Yewdell, Jayanta Chaudhuri
Nov 5, 1999·International Immunology·I Levan-PetitJ C Lecron
Jun 20, 2017·The Journal of Allergy and Clinical Immunology·Jin-Young MinBruce K Tan
Apr 17, 2018·Médecine sciences : M/S·Hussein IssaouiYves Denizot
May 8, 2018·European Journal of Immunology·Cindy GutzeitAndrea Cerutti
Aug 7, 2012·European Journal of Immunology·Andrea CeruttiMontserrat Cols
Aug 24, 2017·PloS One·Dennis K LanningKatherine L Knight
Jul 7, 2007·European Journal of Immunology·Mariella DonoManlio Ferrarini
Nov 15, 2007·European Journal of Immunology·Kaoru KikunoHiromi Kubagawa
Aug 24, 2010·Immunological Reviews·Kang Chen, Andrea Cerutti
Aug 24, 2010·Immunological Reviews·Taketoshi YoshidaBimba F Hoyer
May 11, 2010·Immunological Investigations·Per Brandtzaeg

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