The Notch and Sonic hedgehog signalling pathways in immunity

Molecular Immunology
Robert A BensonSarah E M Howie

Abstract

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

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