The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica

Open Biology
Paula IrlesMaria-Dolors Piulachs

Abstract

The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell fate decisions and the induction of the mitosis-to-endocycle switch in follicular cells (FCs). This work reports the functions of the main components of the Notch pathway (Notch and its ligands Delta and Serrate) during oogenesis in Blattella germanica, a phylogenetically basal species with panoistic ovary. As is revealed by RNAi-based analyses, Notch and Delta were found to contribute towards maintaining the FCs in an immature, non-apoptotic state. This ancestral function of Notch appears in opposition to the induction of transition from mitosis to endocycle that Notch exerts in Drosophila melanogaster, a change in the Notch function that might be in agreement with the evolution of the insect ovary types. Notch was also shown to play an active role in inducing ovarian follicle elongation via the regulation of the cytoskeleton. In addition, Delta and Notch interactions were seen to determine the differentiation of the posterior population of FCs. Serrate levels were found to be N...Continue Reading

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Citations

Aug 6, 2016·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Sylvain MarcelliniFederico D Brown
Jun 14, 2018·Experimental and Therapeutic Medicine·Hai-Yan SongYu-Xiang Zhang
Nov 15, 2019·Cellular and Molecular Life Sciences : CMLS·Jiasheng Song, Shutang Zhou
Apr 26, 2021·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·José Carlos MontañésJosé Luis Maestro

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Methods Mentioned

BETA
PCR

Software Mentioned

Ovariole
Relative Expression Software Tool ( REST )
rimer
REST
raph P ad P rism 6 Demo

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