The Notch transcription activation complex makes its move

Cell
Doug Barrick, Raphael Kopan

Abstract

Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.

References

Sep 28, 1995·Nature·S JarriaultA Israel
Oct 24, 2003·Protein Science : a Publication of the Protein Society·Mark E ZweifelDoug Barrick
Aug 7, 2004·The EMBO Journal·Rhett A Kovall, Wayne A Hendrickson
Sep 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Cecilia C Mello, Doug Barrick
May 9, 2006·Cell·Christopher W Wilson, Pao-Tien Chuang

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Citations

Apr 19, 2008·Nature Reviews. Immunology·Iannis AifantisSilvia Buonamici
Sep 2, 2008·Oncogene·D BellaviaI Screpanti
Apr 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cecilia SahlgrenUrban Lendahl
Jun 21, 2011·The Journal of Biological Chemistry·Sheu-Fen LeeGang Yu
Sep 19, 2008·Journal of Cell Science·Wendy R GordonStephen C Blacklow
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yunsun NamStephen C Blacklow
Jul 7, 2011·Cellular Oncology (Dordrecht)·Agon HyseniPaul J van Diest
May 12, 2010·Cellular and Molecular Life Sciences : CMLS·Rajendran SanalkumarJackson James
Nov 10, 2006·Critical Reviews in Biochemistry and Molecular Biology·David B Doroquez, Ilaria Rebay
Feb 14, 2012·Structure·Sung Hee ChoiStephen C Blacklow
May 23, 2009·Developmental Cell·Mark E Fortini
Apr 22, 2009·Cell·Raphael Kopan, Maria Xenia G Ilagan
Apr 27, 2016·Molecular Genetics and Genomics : MGG·Bao ZhangHuanling Wang
Jun 16, 2016·Frontiers in Cellular and Infection Microbiology·Taslima T LinaJere W McBride
Feb 22, 2012·Developmental Cell·José Luis de la Pompa, Jonathan A Epstein
May 21, 2008·Molecular and Cellular Biology·Kai-Wen HsuTien-Shun Yeh
Aug 18, 2006·Development·Louisa S TangFred A Pereira
Dec 7, 2006·Science's STKE : Signal Transduction Knowledge Environment·Matthias EhebauerAlfonso Martinez-Arias

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