The novel adjuvant dmLT promotes dose sparing, mucosal immunity and longevity of antibody responses to the inactivated polio vaccine in a murine model

Vaccine
Elizabeth B NortonJohn D Clements

Abstract

One option for achieving global polio eradication is to replace the oral poliovirus vaccine (OPV), which has the risk of reversion to wild-type virulence, with the inactivated poliovirus vaccine (IPV) vaccine. Adjuvants and alternate routes of immunization are promising options that may reduce antigen dose in IPV vaccinations, potentially allowing dose sparing and cost savings. Use of adjuvants and alternate routes of immunization could also help promote mucosal immunity, potentially mimicking the protection against intestinal virus shedding seen with OPV. In the current study, we examined the impact of combining the novel adjuvant dmLT with trivalent IPV for dose sparing, induction of mucosal immunity and increasing longevity of anti-poliovirus (PV) responses in a mouse model following either intradermal (ID) or intramuscular (IM) delivery. We found that non-adjuvanted ID delivery was not superior to IM delivery for fractional dose sparing, but was associated with development of mucosal immunity. Vaccination with IPV+dmLT promoted serum anti-PV neutralizing antibodies with fractional IPV doses by either IM or ID delivery, achieving at least five-fold dose sparing above non-adjuvanted fractional doses. These responses were most...Continue Reading

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Citations

Feb 26, 2016·Expert Review of Vaccines·Heleen KraanJean-Pierre Amorij
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kevin Ita
Nov 11, 2016·Future Microbiology·Radboud J Duintjer Tebbens, Kimberly M Thompson
Mar 14, 2017·Expert Review of Vaccines·Nidhi ChauhanUtkarsh Jain
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Oct 14, 2017·Archives of Pharmacal Research·Rakesh BastolaSangkil Lee
Apr 29, 2016·Clinical and Vaccine Immunology : CVI·John D Clements, Lucy C Freytag
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Jul 27, 2018·MSphere·John D Clements, Elizabeth B Norton
Jan 10, 2021·Advanced Drug Delivery Reviews·Jeroen PolletUlrich Strych
Apr 14, 2021·Human Vaccines & Immunotherapeutics·Ting ZhaoJingsi Yang
Jul 3, 2021·Microorganisms·Richard WalkerLouis Bourgeois
Jul 10, 2021·Mucosal Immunology·Ruth I ConnorPeter F Wright

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