The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis

Endocrinology
Gabrielle C DouglasRebecca A Lew

Abstract

The metallopeptidase angiotensin-converting enzyme (ACE) plays a pivotal role in the cardiovascular system by generating the vasoconstrictor peptide angiotensin II. A homolog of ACE with different substrate specificity, ACE2, has recently been cloned that shows an expression pattern restricted to endothelial cells of the heart and kidney, epithelial cells of the distal tubule of the kidney, and the testis. Although the importance of ACE2 to cardiac function is already evident, its role in the testis remains unknown. In this study, we report the cloning and expression of human testicular ACE2 and confirm that it is identical to the somatic form of the enzyme. ACE2 catalytic activity was present in membrane preparations of whole testes and Leydig cells from adult rats; expression of the protein in Leydig cells was confirmed by Western immunoblot analysis. Using immunohistochemistry, ACE2 expression was confined to the Leydig cells in the rat testis and to Leydig and Sertoli cells in the human testis. Ablation of the Leydig cells in the rat by the specific toxin, ethane dimethane sulfonate, eliminated ACE2-positive cells from the interstitium. Expression of ACE2 in rat Leydig cells was up-regulated during the development of adult-...Continue Reading

Citations

Apr 3, 2010·Journal of Molecular Histology·Augusto B ReisFernando M Reis
Jan 25, 2008·Heart Failure Reviews·María Jesús Ramírez-Expósito, José Manuel Martínez-Martos
Mar 28, 2008·Current Hypertension Reports·Jan WysockiDaniel Batlle
Apr 5, 2011·Nephrology·Sonoo MizuiriAtsushi Aikawa
Oct 14, 2005·Kidney International·Carlos M FerrarioMark C Chappell
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Irving H ZuckerLie Gao
Sep 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kim Brint PedersenEric Lazartigues
Feb 6, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yumiko ImaiJosef M Penninger
Jun 21, 2014·Pharmacological Reports : PR·Magdalena Jasińska-Stroschein, Daria Orszulak-Michalak
Jun 22, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan Wysocki, Daniel Batlle
Jul 30, 2014·Indian Journal of Dermatology·Reza M RobatiShima Younespour
Jan 24, 2012·Gender Medicine·Amanda K SampsonKate M Denton
Apr 21, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·T KwokP C Leung
Dec 1, 2009·Urologic Oncology·Matthias PortMichael Abend
May 2, 2008·Experimental Physiology·Yumiko ImaiJosef M Penninger
May 15, 2009·Journal of Anatomy·Marcelo C LealLuiz R França
Aug 2, 2005·Biochimica Et Biophysica Acta·J L GuyA J Turner
Sep 28, 2007·Biochemical Pharmacology·Daniel W LambertAnthony J Turner
Jun 29, 2006·Diabetes·Jan WysockiDaniel Batlle
Jun 4, 2015·PloS One·Kanako MiyabayashiKen-Ichirou Morohashi
Apr 3, 2019·Journal of Cardiovascular Development and Disease·Ali NehmeKazem Zibara
Feb 14, 2020·International Journal of Clinical Practice·Richard Albert Stein
Jul 3, 2019·Biology of Sex Differences·Melissa C WhiteAmy C Arnold
May 19, 2020·American Journal of Physiology. Endocrinology and Metabolism·Johnny S YounisKarl Skorecki
May 20, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kevin HurAshoke R Khanwalkar
May 27, 2020·Andrology·Donatella PaoliFrancesco Lombardo
Jun 25, 2020·Andrologia·Rahul Vishvkarma, Singh Rajender
Jun 12, 2020·Andrology·Vito A GiagulliVincenzo Triggiani
May 29, 2020·Journal of Assisted Reproduction and Genetics·Amir Arav
Jun 14, 2020·Andrology·Claudia MassarottiCarlo Foresta
Jul 19, 2020·Andrology·Vassilios PapadopoulosMary Samplaski

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