The novel antiobesic HMR1426 reduces food intake without affecting energy expenditure in rats

Obesity Research
Sylvia OrtmannSusanne Klaus

Abstract

To determine the effect of acute and chronic administration of a new food intake-reducing compound (HMR1426) with novel mode of action (retardation of gastric emptying) on body weight development, food intake, and energy metabolism in rats. Adult male Shoe-Wistar rats were implanted with transponders allowing registration of body temperature (Tb) and locomotor activity. HMR1426 (10 or 50 mg/kg) was given orally, and acute (8 hours) and chronic (15 days) effects were measured on food intake, Tb, activity, total energy expenditure (indirect calorimetry), and epididymal adipose tissue mass. The effect of chronic treatment was compared with the effect of sibutramine (10 mg/kg). HMR1426 (50 mg/kg) caused an acute and chronic decrease of food intake. There was no effect on the level and daily pattern of total energy expenditure, Tb, and locomotor activity. Respiratory quotient was acutely decreased by HMR1426 due to reduced food intake. Chronic treatment with HMR1426 decreased weight gain by 31% and epididymal white fat by 24%. Sibutramine caused a respective reduction of 48% and 35%. Energy efficiency was not affected by HMR1426 in contrast to sibutramine, which reduced energy efficiency and transiently increased activity. HMR1426 s...Continue Reading

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Citations

May 6, 2010·The British Journal of Nutrition·Christine K FleissnerMichael Blaut
Aug 9, 2005·Expert Opinion on Emerging Drugs·Marcelo L G Correia, William G Haynes
Jul 25, 2006·Expert Opinion on Investigational Drugs·Marcio C Mancini, Alfredo Halpern
Mar 2, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S KlausS Wolfram
Aug 20, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·R L Kennedy, E Y H Khoo
Jul 21, 2017·Public Health Nutrition·Stephanie ChambersWendy L Wrieden
Apr 23, 2008·Current Protocols in Neuroscience·Pēteris AlbertsRobert A McArthur
Jan 1, 2014·Journal of Nutritional Science·Isabel Walter, Susanne Klaus

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