The novel application of tertiary butyl alcohol in the preparation of hydrophobic drug-HPbetaCD complex

The Journal of Pharmacy and Pharmacology
Zhixuan WangXiaopeng Zhang

Abstract

This report describes a novel application of tertiary butyl alcohol (TBA) in the preparation of hydrophobic drug-hydroxypropyl beta-cyclodextrin (HPbetaCD) complex. The straightforward, economic preparation procedure consists of dissolving both the hydrophobic drug and HPbetaCD in TBA, which is subsequently freeze-dried to give the hydrophobic drug-HPbetaCD complex in the form of a porous powder. TBA was selected as the medium due to it being a good solvent for hydrophobic drug and HPbetaCD; in addition, it is also a versatile lyophilization medium and is widely used in pharmaceutical processes. In this study, ketoprofen and nitrendipine were used as model drugs and their HPbetaCD complexes were prepared by lyophilization of the TBA system. Based on the data from differential scanning calorimetry (DSC) and X-ray diffractometry (XRD), the drugs were amorphous in freeze-dried samples. The infra-red (IR) spectrum indicated that a drug-HPbetaCD interaction took place in the freeze-dried complex. Dissolution experiments showed that the hydrophobic drug dissolved rapidly from the HPbetaCD complex in both simulated gastric juice and simulated intestinal fluid. These results confirmed that this technique produced a hydrophobic drug-HPb...Continue Reading

References

Sep 5, 2001·International Journal of Pharmaceutics·N NiS H Yalkowsky
Feb 19, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dirk L Teagarden, David S Baker
Dec 18, 2003·Drug Development and Industrial Pharmacy·Han-Gon ChoiChul-Soon Yong
Mar 5, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D J van DroogeH W Frijlink
May 5, 2004·Journal of Pharmaceutical Sciences·Chunlei Li, Yingjie Deng
Jun 24, 2004·Pharmaceutical Research·Elvire FournierJean-Christophe Leroux
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·D J van DroogeH W Frijlink

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Ana FigueirasFrancisco J B Veiga
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Kale RajendrakumarTayade Pralhad
© 2021 Meta ULC. All rights reserved