The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration

Cell Death & Disease
Claudia DolltAstrid Schmieder

Abstract

Melanoma is a highly immunogenic tumor with a good response to treatment with immune checkpoint inhibitors. Tumor-associated macrophages (TAMs) play an important immunosuppressive role in such tumors and have therefore been identified as possible future therapeutic targets in oncology. The aim of this study was to identify novel immunoregulatory receptors specifically expressed on TAM. Expression of Slamf9, a member of the signaling lymphocytic-activating molecule (Slam) immunoreceptor family, was found to be upregulated in a gene expression analysis of murine bone marrow-derived macrophages (BMDM) stimulated with tumor-conditioned medium of B16F1 melanoma cells. SLAMF9+ macrophages were identified in human and murine melanomas by using self-generated antibodies against human and murine SLAMF9. A comprehensive immunohistochemical analysis of tissue microarrays detected SLAMF9+ TAM in 73.3% of human melanomas, but also in 95.5% of naevi of melanoma patients and in 50% of naevi from healthy controls. In addition, 20% of melanomas and 2.3% of naevi from melanoma patients displayed a positive SLAMF9 expression also in melanocytic cells. No SLAMF9 expression was detected in naevus cells of healthy donors. Although SLAMF9 has no intr...Continue Reading

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Citations

Nov 21, 2019·Vaccines·Patrick O'ConnellYasser A Aldhamen
Jul 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lital SeverIdit Shachar
Jun 7, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Joseph A MikulinTimothy J Wilson
Sep 27, 2020·Journal of Hematology & Oncology·Junqing WuGuoji Guo
Sep 24, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raquibul HannanJames Brugarolas

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Methods Mentioned

BETA
transgenic
ELISA
PMA
dot blot
electrophoresis
PCR

Software Mentioned

Elements Advanced
GraphPad Prism
NIS
ImageJ
SAS JMP7 Genomics
GraphPad

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