The novel marker LTBP2 predicts all-cause and pulmonary death in patients with acute dyspnoea

Clinical Science
Tobias BreidthardtChristian Mueller

Abstract

The risk stratification in patients presenting with acute dyspnoea remains a challenge. We therefore conducted a prospective, observational cohort study enrolling 292 patients presenting to the emergency department with acute dyspnoea. A proteomic approach for antibody-free targeted protein quantification based on high-end MS was used to measure LTBP2 [latent TGF (transforming growth factor)-binding protein 2] levels. Final diagnosis and death during follow-up were adjudicated blinded to LTBP2 levels. AHF (acute heart failure) was the final diagnosis in 54% of patients. In both AHF (P<0.001) and non-AHF (P=0.015) patients, LTBP2 levels at presentation were significantly higher in non-survivors compared with survivors with differences on median levels being 2.2- and 1.5-fold respectively. When assessing the cause of death, LTBP2 levels were significantly higher in patients dying from pulmonary causes (P=0.0005). Overall, LTBP2 powerfully predicted early pulmonary death {AUC (area under the curve), 0.95 [95% CI (confidence interval), 0.91-0.98]}. In ROC (receiver operating characteristic) curve analyses for the prediction of 1-year mortality LTBP2 achieved an AUC of 0.77 (95% CI, 0.71-0.84); comparable with the predictive potenti...Continue Reading

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Citations

Nov 19, 2013·Journal of Cardiac Failure·Tobias BreidthardtChristian Mueller
May 12, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Ian B RobertsonDaniel B Rifkin
Oct 24, 2013·Matrix Biology : Journal of the International Society for Matrix Biology·Mohamed A SideekMark A Gibson
Feb 19, 2015·Biomarkers in Medicine·Wouter Laroy, Paul Ladestein
Dec 20, 2014·Biomarkers in Medicine·Michael HaaseAnja Haase-Fielitz
May 7, 2016·PloS One·Markus H KuehnGillian J McLellan

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