PMID: 8590460Jul 1, 1995Paper

The novel nuclear gene DSS-1 of Saccharomyces cerevisiae is necessary for mitochondrial biogenesis

Current Genetics
Aleksandra DmochowskaPiotr P Stepien

Abstract

A previously unknown nuclear gene DSS-1 from Saccharomyces cerevisiae was cloned and sequenced. The gene was isolated as a multicopy suppressor of a disruption of the SUV-3 gene coding for a DEAD/H box protein involved in processing and turnover of mitochondrial transcripts. The DSS-1 gene codes for a 970 amino-acid protein of molecular weight 111 kDa and is necessary for mitochondrial biogenesis. Amino-acid sequence analysis indicates the presence of motifs characteristic for Escherichia coli RNase II, the dis3 protein from Schizosaccharomyces pombe, the cyt4 protein participating in RNA processing and turnover in Neurospora crassa mitochondria, and the vacB protein from Shigella flexneri. We suggest that the DSS-1 protein may be a component of the mitochondrial 3'-5' exoribonuclease complex.

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Citations

Jun 12, 2003·Journal of Molecular Biology·Jan PiwowarskiPiotr P Stepien
Aug 12, 2003·Gene·Edward SilvermanRen-Jang Lin
Aug 27, 2005·Mitochondrion·Emine Cavdar Koc, Linda L Spremulli
Sep 14, 2011·The Journal of Biological Chemistry·Xuning Emily GuoPhang-Lang Chen
Aug 6, 2008·The Journal of Biological Chemistry·Lily KhidrWen-Hwa Lee
Dec 12, 2012·Nucleic Acids Research·Lukasz S BorowskiRoman J Szczesny
Sep 24, 2005·The FEBS Journal·Michal MinczukPiotr P Stepien
May 31, 2006·Pharmacology & Therapeutics·Devanand Sarkar, Paul B Fisher
May 31, 2012·The Biochemical Journal·Joanna Rorbach, Michal Minczuk
Mar 5, 2013·Biochimica Et Biophysica Acta·Roman J SzczesnyPiotr P Stepien
Jul 1, 1996·Current Biology : CB·J S Anderson, R Parker
Dec 20, 2011·Biochimica Et Biophysica Acta·Roman J SzczesnyPawel Golik
Feb 29, 2008·Journal of Molecular Biology·Bastian HoffmannBernd Schafer
Feb 2, 2010·Biochimica Et Biophysica Acta·Lukasz S BorowskiPiotr P Stepien
May 18, 2004·Trends in Genetics : TIG·Dominique GagliardiZofia M A Chrzanowska-Lightowlers
Sep 25, 1998·Critical Reviews in Biochemistry and Molecular Biology·A LükingU Schmidt
Jun 27, 1997·The Journal of Biological Chemistry·Y UesonoY Kikuchi
Dec 10, 1998·Microbiology·Chung-Yung Chen, John Rosamondt
Aug 28, 2021·Cells·Jigeesha Mukhopadhyay, Georg Hausner

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