The Novel Nutraceutical KJS018A Prevents Hepatocarcinogenesis Promoted by Inflammation

Evidence-based Complementary and Alternative Medicine : ECAM
Do Luong HuynhDong Kee Jeong

Abstract

Inflammation is tightly associated with carcinogenesis at both the initiation and development of tumor. Many reports indicated that Cox-2 substantially contributes to inflammation and tumorigenesis. The novel nutraceutical KJS018A (BRM270 Function Enhanced Products) is the extract mixture from 8 herbal plants, which have been used to inhibit cancers and inflammation. The aim of the present study is to examine the inhibitory effects of KJS018A mixture to hepatocarcinogenesis and inflammation. The results showed that KJS018A significantly inhibited the proliferation of hepatic malignant cells and downregulated levels of IL-6 and Cox-2. Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway. Furthermore, KJS018A suppressed metastatic traits of hepatic malignant cells via downregulating Twist, N-cadherin, and MMP-9 while restoring E-cadherin expression. KJS018A also restrained tumor growth and levels of IL-6 and Cox-2 in immunohistochemistry staining. Taken together, these data suggest potential application of KJS018A in prevention of hepatocarcinogenesis promoted by inflammation.

References

Oct 29, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·G ZhaoP N Kao
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dan D HershkoPer-Olof Hasselgren
Sep 18, 2004·Cancer Letters·Shan ZhaAngelo M De Marzo
Feb 1, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenneth K WuKatarzyna Cieslik
Feb 18, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Norifumi TakedaRyozo Nagai
Jul 1, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christoph RummelGiamal N Luheshi
Jul 7, 2007·Sub-cellular Biochemistry·Randall E Harris
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Feb 11, 2010·Molecular Cancer Research : MCR·Hui-Wen LoFrancis Ali-Osman
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Jun 2, 2012·Cancer Treatment Reviews·Yuqi GuoZhan Zhang
Nov 12, 2013·BMC Complementary and Alternative Medicine·Yu-Jin HwangKyung-A Hwang
Apr 26, 2014·Cancers·Sarah R WalkerDavid A Frank
Mar 11, 2015·Journal of Cellular Physiology·Wan-Yu ChouYuh-Lin Wu
Jun 28, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ah Young LeeMyung-Haing Cho
Feb 13, 2016·Journal of Hepatology·Dirk Schmidt-Arras, Stefan Rose-John
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Neeraj KumariAnant Narayan Bhatt
Jan 23, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Raj Kumar MongreDong Kee Jeong

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Methods Mentioned

BETA
FACS
PMA
xenografting

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