Nov 14, 2019

The Novel Perspectives of Adipokines on Brain Health

International Journal of Molecular Sciences
Thomas Ho-Yin LeeSuk-Yu Yau

Abstract

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the endocrine system. Precisely, adipose tissue can produce an array of bioactive factors, including cytokines, lipids, and extracellular vesicles, which target various systemic organ systems to regulate metabolism, homeostasis, and immune response. The global effects of adipokines on metabolic events are well defined, but their impacts on brain function and pathology remain poorly defined. Receptors of adipokines are widely expressed in the brain. Mounting evidence has shown that leptin and adiponectin can cross the blood-brain barrier, while evidence for newly identified adipokines is limited. Significantly, adipocyte secretion is liable to nutritional and metabolic states, where defective circuitry, impaired neuroplasticity, and elevated neuroinflammation are symptomatic. Essentially, neurotrophic and anti-inflammatory properties of adipokines underlie their neuroprotective roles in neurodegenerative diseases. Besides, adipocyte-secreted lipids in the bloodstream can act endocrine on the distant organs. In this article, we have reviewed five adipokines (leptin, adiponectin, chemerin, apelin, visfatin) and two lipokines (palmitoleic a...Continue Reading

  • References
  • Citations3

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations3

Mentioned in this Paper

Immune Response
Adiponectin
Brain
Nicotinamide Phosphoribosyltransferase
Nerve Degeneration
Apelin-13 peptide, mouse
palmitoleic acid
ADIPOQ
Organ
Neuronal Plasticity

Related Feeds

Blood-Brain Barrier Transport in Neurodegeneration

The Blood-Brain Barrier (BBB) is essential in regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the BBB can be important for regulating drug movement in the brain and dysregulation of these processes may play a role in neurodegenerative disorders. Discover the latest research on BBB transporters here.

Blood Brain Barrier & Cytokines

Cytokines can affect the central nervous system through crossing the blood brain barrier and entering the CSF and interstitial fluid spaces. Some cytokines are able to cross through transport systems and can affect tissues within the CNS, whereas others are unable to cross. Here is the latest research on the blood brain barrier and cytokines.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

International Journal of Molecular Sciences
Iona J MᵃᶜDonaldChih-Hsin Tang
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Ales Smekal, Jan Vaclavik
Mediators of Inflammation
Patricia Fernández-RiejosVíctor Sánchez-Margalet
Molecular Medicine
Katja RabeUli C Broedl
© 2020 Meta ULC. All rights reserved