The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

Immunity
M A Degli-EspostiR G Goodwin

Abstract

A fourth member of the emerging TRAIL receptor family, TRAIL-R4, has been cloned and characterized. TRAIL-R4 encodes a 386-amino acid protein with an extracellular domain showing 58%-70% identity to those of TRAIL-R1, TRAIL-R2, and TRAIL-R3. The signaling capacity of TRAIL-R4 is similar to that of TRAIL-R1 and TRAIL-R2 with respect to NF-kappaB activation, but differs in its inability to induce apoptosis. Yet TRAIL-R4 retains a C-terminal element containing one third of a consensus death domain motif. Transient overexpression of TRAIL-R4 in cells normally sensitive to TRAIL-mediated killing confers complete protection, suggesting that one function of TRAIL-R4 may be inhibition of TRAIL cytotoxicity. Like TRAIL-R1 and TRAIL-R2, this receptor shows widespread tissue expression. The human TRAIL-R4 gene has been mapped to chromosome 8p22-21, clustered with three other TRAIL receptors.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Mar 10, 1995·Science·S Nagata, P Golstein
Sep 10, 1993·Cell·L A TartagliaD V Goeddel
May 31, 1996·The Journal of Biological Chemistry·R M PittiA Ashkenazi
Jun 1, 1996·Current Opinion in Immunology·L Van Parijs, A K Abbas
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Apr 4, 1997·Science·G PanV M Dixit
Jul 10, 1997·Nature·M IrmlerJ Tschopp
Oct 6, 1997·The EMBO Journal·H WalczakC T Rauch
Oct 7, 1997·The Journal of Experimental Medicine·M A Degli-EspostiC A Smith

❮ Previous
Next ❯

Citations

May 29, 1998·European Journal of Immunology·S M Mariani, P H Krammer
Jul 13, 2000·Microscopy Research and Technique·H T Idriss, J H Naismith
Apr 11, 2001·Head & Neck·B R Gastman
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W A Faubion, G J Gores
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Andreas EvdokiouDavid M Findlay
Oct 18, 2002·International Journal of Cancer. Journal International Du Cancer·Susanne SeitzSiegfried Scherneck
Jun 19, 2001·International Journal of Cancer. Journal International Du Cancer·E C ShinJ H Park
Jun 7, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Songqing HeShaofa Wang
Jul 18, 2001·Pathology Oncology Research : POR·I Peták, J A Houghton
May 28, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Edwin BremerWijnand Helfrich
May 19, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Olaf HoffmannJoerg R Weber
Aug 15, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tom M GantenHenning Walczak
Sep 28, 2005·Cancer Immunology, Immunotherapy : CII·Koji Tamada, Lieping Chen
May 3, 2005·Cancer Immunology, Immunotherapy : CII·Thomas J Sayers, William J Murphy
Aug 1, 2007·Cancer Immunology, Immunotherapy : CII·Julia StieglmaierWijnand Helfrich
Dec 18, 2008·Cancer Immunology, Immunotherapy : CII·Nancy Lynn BoothCurtis J Henrich
Nov 6, 2013·Archives of Gynecology and Obstetrics·Letícia da Conceição BragaAgnaldo Lopes da Silva Filho
Nov 2, 2005·Journal of Gastroenterology·Hidehiko MatsukawaToshifumi Hibi
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·S BouralexisA Evdokiou
Dec 1, 2006·Apoptosis : an International Journal on Programmed Cell Death·Penny Clarke, Kenneth L Tyler
Jun 15, 2007·Apoptosis : an International Journal on Programmed Cell Death·Silvia ColucciMaria Grano
Jan 1, 2008·Apoptosis : an International Journal on Programmed Cell Death·Sárka SímováLadislav Andera
Feb 6, 2009·Apoptosis : an International Journal on Programmed Cell Death·Thomas Newsom-DavisHenning Walczak
Apr 25, 2007·Breast Cancer Research and Treatment·Natalya V GusevaMichael B Cohen
Aug 26, 2009·International Urology and Nephrology·Omer KutluErdal Kukul
Oct 6, 2007·Immunologic Research·Mark P SimonsThomas S Griffith
Oct 3, 2002·Biochemical and Biophysical Research Communications·Thorsten Berger, Matthias Kretzler
Jan 5, 2002·Journal of Neuroimmunology·Jan DörrFrauke Zipp
Sep 16, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Patrizia MariniClaus Belka
Apr 23, 2003·Cancer Letters·Young-Ju JangHyung-Il Kim
Mar 12, 2003·Toxicology Letters·Marion MacFarlane
Apr 27, 2000·Current Opinion in Immunology·G Screaton, X N Xu
Jun 25, 1998·Current Opinion in Immunology·D WallachM P Boldin
Oct 31, 1998·Current Opinion in Immunology·T S Griffith, D H Lynch
Apr 21, 1999·Current Opinion in Cell Biology·A Ashkenazi, V M Dixit
Mar 26, 2003·Seminars in Cancer Biology·Nesrin Ozören, Wafik S El-Deiry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis