The novel role of miRNAs for tamoxifen resistance in human breast cancer

Cellular and Molecular Life Sciences : CMLS
Wenwen ZhangXiaoxiang Guan

Abstract

The selective estrogen receptor modulator tamoxifen is the most commonly used treatment for patients with ER-positive breast cancer. However, tumor cells often develop resistance to tamoxifen therapy, which is a major obstacle limiting the success of breast cancer treatment. miRNAs, as oncogenic or tumor suppressor genes, regulate the expression and function of their related target genes to affect the biological behaviors of cancer cells, including cancer initiation, progression, metastasis, and therapeutic resistance. In detail, many miRNAs associated with breast cancer tamoxifen resistance have been identified, which offer new targets for breast cancer therapy. Here, we review the miRNAs involved in regulation of tamoxifen resistance in human breast cancer and the mechanism of how the modulation of miRNAs may regulate the sensitivity of breast cancer cells to tamoxifen. We also discuss the future prospects of studies about miRNAs in regulation of tamoxifen resistance and miRNA-based therapeutics for tamoxifen resistance breast cancer patients.

References

Oct 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M ClarkW L McGuire
Feb 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I A JaiyesimiG N Hortobagyi
Jan 1, 1993·Breast Cancer Research and Treatment·C C BenzC K Osborne
Nov 10, 1998·Molecular Carcinogenesis·K Y Kwong, M C Hung
Nov 26, 1998·The New England Journal of Medicine·C K Osborne
Sep 27, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gudrun PohlMartin Filipits
Nov 17, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Robin L KilkerMaricarmen D Planas-Silva
Mar 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Carolina GutierrezMitch Dowsett
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Kent Osborne, Rachel Schiff
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michele De LaurentiisSabino De Placido
Sep 17, 2005·Biochemical and Biophysical Research Communications·Zhaoyi WangThomas F Deuel
Jan 13, 2006·Cardiovascular Research·Hideaki NagaseGillian Murphy
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
May 13, 2006·Nucleic Acids Research·Scott DavisChristine Esau
Mar 17, 2007·The Journal of Biological Chemistry·Shuomin ZhuYin-Yuan Mo
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Margaretha RudasUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Mar 21, 2008·Nature Reviews. Cancer·Isabel M ChuJoyce M Slingerland
Jun 24, 2008·Critical Reviews in Clinical Laboratory Sciences·William Cruz-Munoz, Rama Khokha
Aug 19, 2008·The Journal of Biological Chemistry·Tyler E MillerSarmila Majumder
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jozien HellemanEls M J J Berns
Dec 17, 2008·Molecular Cancer Therapeutics·Kristen M Nelson, Glen J Weiss
Mar 21, 2009·Journal of Cellular and Molecular Medicine·Xiaoxiang GuanMacus Tien Kuo
May 6, 2009·Molecular and Cellular Biology·Deo Prakash Pandey, Didier Picard
Jun 3, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Liang ShiYuntao Xie
Oct 21, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Virginia G KaklamaniRuth M O'Regan
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jan 22, 2010·The Journal of Investigative Dermatology·Dario AntoniniCaterina Missero
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexandra F LearyStephen R D Johnston
Mar 30, 2010·Journal of Experimental & Clinical Cancer Research : CR·Bao SongXianrang Song
Aug 27, 2010·Current Opinion in Oncology·Michael A TesselSteven T Rosen
Dec 22, 2010·Molecular Cancer·Diana M CittellyFrank E Jones
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman

❮ Previous
Next ❯

Citations

Jul 19, 2015·Biochemical and Biophysical Research Communications·Helen Shiphrah VethakanrajSekar Ashok Kumar
Aug 23, 2016·International Journal of Molecular Sciences·Milena Rondón-LagosPeter G Zaphiropoulos
Nov 6, 2018·The Journal of Endocrinology·Zerui WuZhipeng Su
Dec 14, 2017·Breast Cancer Research and Treatment·Hehui FangXiaoxiang Guan
Apr 13, 2021·Frontiers in Endocrinology·Esmael Besufikad Belachew, Dareskedar Tsehay Sewasew
Aug 28, 2021·Cancers·Angeliki AndrikopoulouFlora Zagouri
Oct 1, 2021·Frontiers in Oncology·Jin-Hai TianLi-Bin Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Expert Review of Gastroenterology & Hepatology
Liu HongDaiming Fan
Cancers
Ryou-U TakahashiTakahiro Ochiya
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Amy M FowlerD Craig Allred
© 2021 Meta ULC. All rights reserved