The novel trinuclear platinum complex BBR3464 induces a cellular response different from cisplatin

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Tiziana ServideiRiccardo Riccardi

Abstract

BBR3464 is a new platinum-based drug non cross-resistant with cisplatin. To characterise the cellular basis of BBR3464 cytotoxicity as opposed to cisplatin, we performed a comparative study of the two drugs in cisplatin-resistant neuroblastoma and astrocytoma cells. In both model systems, BBR3464 proved to be more potent than cisplatin and was able to overcome cisplatin resistance. The higher potency exhibited by BBR3464 correlated with an increased cellular platinum accumulation and DNA-adduct formation. At equitoxic doses, BBR3464 induced apoptosis to a lesser extent than cisplatin and failed to overcome the decreased susceptibility to cisplatin-induced apoptosis in cisplatin-resistant cells. Cell cycle analysis showed a dose-dependent G2/M arrest by BBR3464. In astrocytoma cells, cisplatin treatment resulted in the upregulation of p53, p21 and bax, while only p21 induction was observed after BBR3464 treatment. In cisplatin-resistant cells, the reduced sensitivity to cisplatin paralleled a resistance to the induction of p53/p21 pathway by cisplatin, while the same doses of BBR3464 induced p21 to a similar extent in the resistant cells as in the parental cells. In conclusion, BBR3464 induces a cellular response that is differe...Continue Reading

References

May 2, 1990·Journal of the National Cancer Institute·C M SorensonA Eastman
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L AgarwalG R Stark
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·D LinW E Mercer
Oct 28, 1993·The New England Journal of Medicine·C C Harris, M Hollstein
Jun 7, 1996·Biochimica Et Biophysica Acta·T M Gottlieb, M Oren
Sep 27, 1996·International Journal of Cancer. Journal International Du Cancer·A FajacJ Bénard
Apr 16, 1998·The Journal of Biological Chemistry·T ServideiS A Reeves
Nov 5, 1999·Current Opinion in Oncology·J A Houghton
Aug 15, 2000·Leukemia·M V Blagosklonny

❮ Previous
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Citations

Aug 28, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V CeperoA Carnero
Sep 19, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Viktor Brabec, Jana Kasparkova
Aug 10, 2010·Chemical Communications : Chem Comm·John B Mangrum, Nicholas P Farrell
May 30, 2012·Cancer Cell International·Johan KjellströmJohan Wennerberg
Nov 12, 2003·Reproductive Biology and Endocrinology : RB&E·Michael FraserBenjamin K Tsang
Sep 7, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jakub FlorianViktor Brabec
Dec 17, 2015·Chemistry : a European Journal·Dale L AngJanice Aldrich-Wright
Sep 1, 2015·Journal of Molecular Graphics & Modelling·Lucas F EstevesLuiz Antônio S Costa
Jan 23, 2016·Critical Reviews in Oncology/hematology·Mohamed AlorabiApar Kishor Ganti
Oct 27, 2009·European Journal of Medicinal Chemistry·Francisco J Ramos-LimaCarmen Navarro-Ranninger
Dec 19, 2008·Pharmacology & Therapeutics·Nina F Schor
Nov 28, 2002·Clinical Colorectal Cancer·Kevin P McMullen, A William Blackstock
Jul 26, 2008·Journal of Inorganic Biochemistry·Nial J Wheate
Jun 27, 2007·Journal of Inorganic Biochemistry·Ase Sykfont SnyggSofi K C Elmroth
Jan 15, 2005·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Ana M AmadoLuis A E Batista de Carvalho
Aug 27, 2003·Medicinal Research Reviews·Li-June Ming
Dec 20, 2007·International Journal of Cancer. Journal International Du Cancer·Parvesh ChaudhrySiddhartha Majumdar
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Ho-Shin GwakOliver Bögler
Feb 24, 2005·Seminars in Oncology·Nicholas P Farrell
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Paola PeregoFranco Zunino
Dec 15, 2007·Journal of Inorganic Biochemistry·Timo KappBrigitte Kircher
Jan 6, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Nial J WheateJ Grant Collins
Oct 14, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Angeles MedranoAdoracion G Quiroga
Nov 21, 2007·The Journal of Chemical Physics·Ana M AmadoLuis A E Batista de Carvalho
Jun 14, 2005·Molecular & Cellular Proteomics : MCP·Christine BilleckeOliver Bögler
Jul 2, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Nial J WheateRabbab Oun
May 22, 2019·Veterinary and Comparative Oncology·Marta HenklewskaBozena Obminska-Mrukowicz
Nov 6, 2018·Current Medicinal Chemistry·Xiao XiaoWenliang Li
Mar 21, 2007·Biochemical Society Transactions·M P M Marques, L A E Batista de Carvalho
Jan 8, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Carolin MüggeWolfgang Weigand
Feb 14, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rui WangXiabin Jing
Feb 26, 2021·Annals of Surgical Oncology·Caitlin T Demarest, Andrew C Chang
Apr 5, 2007·Journal of Medicinal Chemistry·Francisco J Ramos-LimaCarmen Navarro-Ranninger

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