The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML

Leukemia Research
E A RushR L Redner

Abstract

The PML protein localizes to regions of the nucleus known as nuclear bodies or PODs. However, in t(15;17) Acute Promyelocytic Leukemia (APL) blasts, PML is found in a micro-punctate pattern. In order to test the hypothesis that delocalization of PML from PODs is necessary for APL, we investigated the interaction of the t(5;17) APL fusion protein NPM-RAR with PML. NPM-RAR localizes diffusely throughout the nucleoplasm. NPM-RAR does not alter the localization of PML in transfected HeLa cells, and does not associate with PML in vitro. These studies suggest that NPM-RAR does not interact with PML.

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Citations

Jan 13, 2016·Leukemia & Lymphoma·Erin M SwaneyRobert L Redner
Jun 7, 2008·Leukemia Research·Jana KrejcíEva Bártová
Sep 21, 2006·Cancer Science·Tomoki NaoeTakeshi Urano
Jul 19, 2014·Molecular Cancer Research : MCR·Anuja ChattopadhyayRobert L Redner

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