The NRAMP1, VDR, TNF-α, ICAM1, TLR2 and TLR4 gene polymorphisms in Iranian patients with pulmonary tuberculosis: A case-control study

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Mohammad JafariNader Tajik

Abstract

The innate immune response drives early events in Mycobacterium tuberculosis infection. Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population. We conducted an association study and included 96 patients and 122 matched healthy individuals. We used single ARMS-PCR technique to simultaneously genotype fourteen polymorphisms in this survey. Among all fourteen polymorphisms that were examined, three polymorphisms were significantly different between case and control groups. The TNF -308A polymorphism showed significant increase in allele and genotype frequencies among patients compared to control individuals [-308A allele: 19.3 vs. 9.4%, GA genotype: 28.1 vs. 17.2%, AA genotype: 5.2 vs. 0.8%; Corrected P (Pc)<0.05], and the TLR4 variant allele and genotypes prevalence (D299G and T399I) were significantly higher among patient...Continue Reading

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Citations

Jul 8, 2017·Tropical Medicine & International Health : TM & IH·Hoang van TongChristian G Meyer
Oct 24, 2017·International Journal of Immunogenetics·M QrafliK Sadki
Jul 19, 2017·Pathogens and Global Health·Majid Faridgohar, Hassan Nikoueinejad
Aug 31, 2020·International Journal of Mycobacteriology·Jalaledin GhanaviAli Akbar Velayati
Sep 1, 2018·Frontiers in Medicine·Murugesan HarishankarRamalingam Bethunaickan
Jun 21, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Shouquan WuJian-Qing He
Feb 10, 2021·International Journal of Molecular Sciences·Shruthi ThadaSanne Burkert
Apr 27, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Upendra YadavVandana Rai

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