The nuclear dehydrogenation of steroids by intestinal bacteria

Journal of Medical Microbiology
P GoddardP Barnes

Abstract

We have postulated that bacteria able to dehydrogenate the bile-acid nucleus are important in the aetiology of cancer of the colon. In this paper we report on screening for the ability to carry out two such reactions. The relevant enzymes are produced by a high proportion of strains of Clostridium paraputrificum, C. tertium and C. indolis, and by small numbers of strains in other clostridial species, but not by organisms of the other genera tested. Strains able to dehydrogenate the bile-acid nucleus represent a high proportion of the lecithinase-negative clostridia isolated from faeces of people living in Britain but a low proportion of those from people living in Uganda or Hong Kong.

Citations

Aug 1, 1978·Journal of Steroid Biochemistry·P LombardiS L Gorbach
Jan 1, 1982·Toxicology·J K Chipman
Nov 27, 2001·FEMS Immunology and Medical Microbiology·M MatsumotoY Benno
Jan 1, 1992·Microbiology and Immunology·Y Benno, T Mitsuoka
Aug 1, 1980·Gut·D VargoM H Floch
May 1, 1985·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·E HaralambieG Linzenmeier
Apr 1, 2010·Journal of the Science of Food and Agriculture·Raquel BedaniElizeu A Rossi
Jan 1, 1986·Microbiology and Immunology·Y BennoT Mitsuoka
Nov 20, 2019·Current Pharmaceutical Design·Yu DongTaisheng Liang
Jan 1, 1993·Journal of Basic Microbiology·H GrohC Hörhold-Schubert

Related Concepts

Androstenedione
Clostridium
Equilenin
Equilin
Feces
Intestines
Oxidase
Phospholipase
Catatoxic Steroids

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