The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO.

The Journal of Biological Chemistry
Jörn LausenMilton H Werner

Abstract

The acute human leukemias are associated with the presence of chimeric gene products that arise from spontaneous chromosomal translocations. The t(8;21) translocation gene product led to the discovery of the Eight Twenty-One (ETO) gene. When fused to RUNX1, ETO is thought to mediate the formation of a repressive complex at RUNX1-dependent genes. ETO has also been found to act as a co-repressor of the promyelocytic zinc finger and Bcl-6 oncoproteins, suggesting that it may play a common role as a transcriptional co-repressor leading to human disease. An analysis of ETO-mediated repression revealed that one of the key binding partners of ETO is the nuclear receptor co-repressor (N-CoR). It is shown that two highly conserved domains of ETO interact with repression domains I and III of N-CoR. One of the ETO domains displays significant homology to Drosophila TAF(II)110, whereas the other is a predicted zinc binding motif that engages a conserved PPLXP motif in repression domain III of N-CoR. Together, these domains of ETO cooperate in repression with N-CoR and the binding sites in N-CoR overlap with those for other repressive factors. Thus, ETO has the potential to participate in a number of repressive complexes, which can be disti...Continue Reading

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Citations

Oct 28, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eun-Young AhnDong-Er Zhang
Jun 6, 2012·International Journal of Peptides·Mythily Srinivasan, A Keith Dunker
Jan 31, 2009·Blood·Liya RoudaiaNancy A Speck
May 1, 2010·Blood·Christian WichmannManuel Grez
Jan 22, 2008·BMC Molecular Biology·Rakesh Singh DhandaInge Olsson
Feb 2, 2013·PloS One·Fatiha KatebMichael Sattler
May 31, 2014·Nature Communications·Stephan KolodziejJörn Lausen
May 6, 2008·The Journal of Biological Chemistry·Raman KumarDavid F Callen

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