The Nuclear Receptor Field: A Historical Overview and Future Challenges

Nuclear Receptor Research
Gisela I MazairaMario D Galigniana

Abstract

In this article we summarize the birth of the field of nuclear receptors, the discovery of untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of the three-domain structure of the receptors, and the properties of the Hsp90-based heterocomplex responsible for the overall structure of the oligomeric receptor and many aspects of the biological effects. The discovery and properties of the subfamily of receptors called orphan receptors is also outlined. Novel molecular aspects of the mechanism of action of nuclear receptors and challenges to resolve in the near future are discussed.

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Citations

Jul 17, 2020·British Journal of Pharmacology·Lorenzo Pontini, Maura Marinozzi
Sep 17, 2020·International Journal of Molecular Sciences·Ami KobayashiSatoshi Inoue
Feb 6, 2019·Biomolecules·Nadia R ZgajnarMario D Galigniana
Aug 15, 2019·International Journal of Molecular Sciences·Ugo Moens, Andrew Macdonald
Jun 2, 2020·Frontiers in Cell and Developmental Biology·Shailly Varma ShrivastavAnuraag Shrivastav
Jun 17, 2020·BMC Microbiology·Gloria BartoloMikhail Martchenko Shilman
Sep 2, 2020·Cells·Prashanta SilwalEun-Kyeong Jo
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Oct 23, 2020·G3 : Genes - Genomes - Genetics·Lesley N Weaver, Daniela Drummond-Barbosa
Feb 12, 2021·Science Advances·Sarah A MosureDouglas J Kojetin
Dec 5, 2020·Molecular Aspects of Medicine·Andrew E LibbyMoshe Levi
Mar 7, 2021·Cellular and Molecular Gastroenterology and Hepatology·Fang-Yuan MaoYuan Zhuang
May 20, 2021·Nature Reviews. Drug Discovery·Matthew J Henley, Angela N Koehler
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Aug 28, 2021·Cells·Youssif Ben ZablahZhengping Jia
Jan 8, 2022·Journal of Biomolecular Structure & Dynamics·Saira CancelaMargot Paulino

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Methods Mentioned

BETA
saturation binding
xenosensors

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