The nuclear receptor ligand-binding domain: structure and function

Current Opinion in Cell Biology
D Moras, Hinrich Gronemeyer

Abstract

In the past few years our understanding of nuclear receptor action has dramatically improved as a result of the elucidation of the crystal structures of the empty (apo) ligand-binding domains of the nuclear receptor and of complexes formed by the nuclear receptor's ligand-binding domain bound to agonists and antagonists. Furthermore, the concomitant identification and functional analysis of co-regulators (transcriptional intermediary factors [TIFs], comprising co-activators and co-repressors) previously predicted from squelching studies, have deepened this understanding. Recent data have provided the structural basis for the specific recognition of ligands and the molecular mechanisms of agonism and antagonism, enabling us to gain a comprehensive view of the early steps of nuclear receptor action.

References

Dec 14, 1995·Nature·R L WagnerR J Fletterick
Feb 1, 1995·Current Biology : CB·V Laudet, G Adelmant
May 18, 1995·Nature·H Gronemeyer, D Moras
Dec 15, 1995·Cell·D J Mangelsdorf, R M Evans
Feb 1, 1996·Nature Structural Biology·J M WurtzH Gronemeyer
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·S Yeh, C Chang
Apr 1, 1997·Current Opinion in Cell Biology·C K GlassM G Rosenfeld
May 1, 1997·Nature·A P Wolffe
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H EscrivaV Laudet
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·H LiJ D Chen
Mar 21, 1998·Nature Structural Biology·B P KlaholzD Moras
Jul 11, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·M GöttlicherP Herrlich

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Citations

Dec 28, 1999·BioFactors·C Carlberg
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Karine SteketeeJan Trapman
Sep 5, 2002·Journal of Cellular Biochemistry·Marcus QuackCarsten Carlberg
Oct 7, 2008·European Biophysics Journal : EBJ·Mikael Peräkylä
Apr 7, 2010·European Biophysics Journal : EBJ·Núria Queralt-Rosinach, Jordi Mestres
Mar 3, 2012·Molecules and Cells·Je-Min Choi, Alfred L M Bothwell
Aug 6, 2008·Journal of Molecular Neuroscience : MN·M K Thakur, Swati Ghosh
Mar 17, 2004·Gene·Julie Bastien, Cécile Rochette-Egly
Feb 6, 2004·Journal of Molecular Biology·Adelia RazetoStefan Becker
May 24, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Tommi ManninenTimo Ylikomi
May 20, 2004·Molecular and Cellular Endocrinology·Johanna HuppunenPiia Aarnisalo
Apr 20, 2005·Molecular and Cellular Endocrinology·Maurizio ZuccottiCarlo Alberto Redi
Jun 8, 2002·Biochemical and Biophysical Research Communications·Jonathan H DennisDavid S Latchman
Jun 18, 2003·Biochemical and Biophysical Research Communications·Bahareh AziziDonald F Doyle
Sep 29, 2000·Biochemical Pharmacology·C CansG Superti-Furga
Aug 11, 2000·Prostaglandins & Other Lipid Mediators·C E ClayF H Chilton
Dec 21, 2000·Trends in Pharmacological Sciences·G J Murphy, J C Holder
Feb 1, 2003·Trends in Pharmacological Sciences·Brian M Necela, John A Cidlowski
Dec 16, 1998·Trends in Pharmacological Sciences·T W Schwartz, A P IJzerman
Dec 11, 1999·Molecular and Biochemical Parasitology·T R UnnaschM W Kennedy
Mar 27, 2001·Biochimica Et Biophysica Acta·S AraiJ Nishikawa
Dec 12, 2001·Molecular and Cellular Endocrinology·I A HughesJ R Hawkins
Mar 26, 2002·Molecular and Cellular Endocrinology·Thierry Van ReethJosiane Szpirer
Jun 29, 2002·Molecular and Cellular Endocrinology·Takako SakamotoShin-ichi Hayashi
Apr 23, 2003·Molecular and Cellular Endocrinology·T M TannerF Claessens
Dec 22, 1999·Current Opinion in Biotechnology·A Mueller-Fahrnow, U Egner
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S Levenson, V C Jordan
Mar 11, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S Levenson, V C Jordan
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·P PissiosD D Moore
Dec 12, 2001·The Journal of Steroid Biochemistry and Molecular Biology·A C Cato, S Mink
Nov 19, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Shin-ichi HayashiYuri Yamaguchi
Jun 19, 2001·Trends in Biochemical Sciences·S Khorasanizadeh, F Rastinejad
May 10, 2001·Trends in Biochemical Sciences·B C Freeman, K R Yamamoto
Feb 1, 2000·Trends in Endocrinology and Metabolism : TEM·X Hu, M A Lazar

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