The nucleolus of Caenorhabditis elegans.

Journal of Biomedicine & Biotechnology
Li-Wei LeeSzecheng J Lo

Abstract

Nucleolar size and appearance correlate with ribosome biogenesis and cellular activity. The mechanisms underlying changes in nucleolar appearance and regulation of nucleolar size that occur during differentiation and cell cycle progression are not well understood. Caenorhabditis elegans provides a good model for studying these processes because of its small size and transparent body, well-characterized cell types and lineages, and because its cells display various sizes of nucleoli. This paper details the advantages of using C. elegans to investigate features of the nucleolus during the organism's development by following dynamic changes in fibrillarin (FIB-1) in the cells of early embryos and aged worms. This paper also illustrates the involvement of the ncl-1 gene and other possible candidate genes in nucleolar-size control. Lastly, we summarize the ribosomal proteins involved in life span and innate immunity, and those homologous genes that correspond to human disorders of ribosomopathy.

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Citations

Mar 14, 2013·Current Opinion in Cell Biology·Rahul Sharma, Peter Meister
Mar 24, 2016·Nucleus·Tian-Hsiang MaSzecheng J Lo
Sep 17, 2013·Biology·Marie Morimoto, Cornelius F Boerkoel
Sep 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Chengming ZhuShouhong Guang
Jul 1, 2020·International Journal of Molecular Sciences·Florian Bo Otto, Michael Thumm
Aug 9, 2021·Nucleic Acids Research·Shimiao LiaoXuezhu Feng

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Methods Mentioned

BETA
GTPases
Fluorescence Microscopy
transgenic
electron microscopy

Software Mentioned

WormAtlas
LDAg

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