The nucleotide diversity of MICA and MICB suggests the effect of overdominant selection

Tissue Antigens
H A ElsnerR Blasczyk

Abstract

The major histocompatibility complex (MHC) class I-related molecules A and B (MICA and MICB) are stress-inducible cell surface antigens that are recognized by immunocytes bearing the receptor NKG2D. In our study we estimated the average number of synonymous (pis) and nonsynonymous nucleotide substitutions (pia) per site in exons 2-4 of MICA and MICB. In exons 2 and 3 of MICB only nonsynonymous substitutions were found, and in exon 3 of MICA pia clearly exceeded pis. This finding is in contrast to the evolutionary parameters found in most other genes, and is reminiscent of the elevated pia values caused by overdominant selection in the peptide-binding region of conventional MHC class I molecules. It may be explained by the hypothetical interaction with nonpeptide antigens, or by resistance against pathogens.

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Citations

Jul 31, 2014·Immunogenetics·Alice MeyerSeiamak Bahram
May 12, 2007·Tissue Antigens·G G M DoxiadisR E Bontrop
Jul 7, 2007·Immunology·Anita R Mistry, Chris A O'Callaghan
Dec 16, 2011·International Journal of Immunogenetics·W Sergio do SacramentoJ E Laguila Visentainer
Aug 18, 2006·Seminars in Cancer Biology·Jérôme D Coudert, Werner Held
May 16, 2006·Human Immunology·Xiaojiang GaoMary Carrington
Apr 3, 2016·Protein Expression and Purification·Shufen WangJun Sheng
Jun 15, 2007·Schizophrenia Research·Brian H ShirtsVishwajit L Nimgaonkar
Sep 27, 2018·Frontiers in Immunology·Dominik Schmiedel, Ofer Mandelboim

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