PMID: 2503233Jun 19, 1989Paper

The nucleus locus coeruleus modulates local cerebral glucose utilization during noise stress in rats

Brain Research
A JusticeL L Brown

Abstract

Local cerebral glucose utilization (LCGU), estimated by the quantitative autoradiographic 2-deoxyglucose technique, was studied in rats with bilateral 6-hydroxydopamine lesions of the locus coeruleus (LC) and in vehicle-injected controls. Unanesthetized animals were studied during exposure to stressful levels of white noise (95 dB) or in relative silence (50 dB). Results indicated that noise caused greater and more widespread increases in LCGU in animals with LC lesions than in vehicle-injected controls. Lesions alone had little or no effect in animals not subjected to noise. Analyses of variance revealed significant treatment interaction effects (intact/lesion x silence/noise) for 37 of 109 regions measured. The pattern of results suggests that the LC acts during stress to limit unnecessary cerebral activity that might interfere with efficient sensory processing and/or the organization of appropriate behavioral responses. In this respect LC function may be similar to those actions of the peripheral sympathetic nervous system that suppress vegetative functions during stress to allow for the performance of coping responses.

References

Jan 1, 1977·Progress in Neurobiology·D G Amaral, H M Sinnamon
Feb 1, 1977·Journal of Comparative and Physiological Psychology·S T Mason, S D Iversen
Nov 9, 1979·Brain Research·N SuenagaT Fukuda
Oct 1, 1987·Brain Research Bulletin·R L CraikB E Levin
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Nov 1, 1974·Journal of Neurochemistry·R A HawkinsR L Veech
Apr 1, 1982·Pharmacology, Biochemistry, and Behavior·B A Pappas, R Ings
Jan 1, 1984·European Journal of Clinical Pharmacology·E Müller-Schweinitzer
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S L FooteF E Bloom
May 1, 1983·Physiology & Behavior·J M KaplanG Wolf
Jan 1, 1981·Progress in Neurobiology·S T Mason
Mar 1, 1981·Brain Research Bulletin·S FujimotoS Takaori

❮ Previous
Next ❯

Citations

Jan 1, 1994·Brain Research Bulletin·K YamamotoM Yoshii
Feb 13, 2001·Biological Psychiatry·J K RillingC D Kilts
Dec 21, 2014·Journal of the Association for Research in Otolaryngology : JARO·Edward LobarinasColleen Le Prell
Mar 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M InoueH M Pappius
Jun 1, 1995·Clinical Pharmacology and Therapeutics·M E SchmidtW Z Potter
May 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L HornumH Markholst
Jun 1, 1998·Annals of the New York Academy of Sciences·Diana Dow-Edwards, Yamit Busidan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.