The NUKDOS software for treatment planning in molecular radiotherapy

Zeitschrift für medizinische Physik
P KlettingG Glatting

Abstract

The aim of this work was the development of a software tool for treatment planning prior to molecular radiotherapy, which comprises all functionality to objectively determine the activity to administer and the pertaining absorbed doses (including the corresponding error) based on a series of gamma camera images and one SPECT/CT or probe data. NUKDOS was developed in MATLAB. The workflow is based on the MIRD formalism For determination of the tissue or organ pharmacokinetics, gamma camera images as well as probe, urine, serum and blood activity data can be processed. To estimate the time-integrated activity coefficients (TIAC), sums of exponentials are fitted to the time activity data and integrated analytically. To obtain the TIAC on the voxel level, the voxel activity distribution from the quantitative 3D SPECT/CT (or PET/CT) is used for scaling and weighting the TIAC derived from the 2D organ data. The voxel S-values are automatically calculated based on the voxel-size of the image and the therapeutic nuclide ((90)Y, (131)I or (177)Lu). The absorbed dose coefficients are computed by convolution of the voxel TIAC and the voxel S-values. The activity to administer and the pertaining absorbed doses are determined by entering the...Continue Reading

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Citations

Aug 31, 2018·EJNMMI Research·Daphne Merel Valerie HuizingMarcellus Petrus Maria Stokkel
Sep 16, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Jonathan I GearGlenn D Flux
Jun 20, 2020·EJNMMI Physics·Andreas RinscheidGerhard Glatting
Feb 17, 2017·Insights Into Imaging·UNKNOWN European Association of Nuclear Medicine (EANM)UNKNOWN European Society for Radiotherapy and Oncology (ESTRO)
Aug 18, 2020·International Journal of Radiation Oncology, Biology, Physics·Sara St JamesYing Xiao
Dec 19, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Peter KlettingGerhard Glatting
Jul 14, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michael Lassmann, Uta Eberlein
Dec 22, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Johannes Tran-GiaMichael Lassmann

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