PMID: 9191902May 1, 1997Paper

The number of clonogenic cells in crypts in three regions of murine large intestine

International Journal of Radiation Biology
W B CaiC S Potten

Abstract

Data are presented for the kinetics of repair of sub-lethal damage in the large intestine of mice. The results are based on experiments using the crypt microcolony assay with two equal sized doses which were delivered with a variable interval of time between the doses. These show that this split-dose repair was largely complete after 5 h, and that there were no significant differences between three regions of the large intestine. Overall the half-time for the repair was 2.3 +/- 0.8 h, and the maximum split-dose repair ratio (the proportion of damage recovered by splitting the dose into two fractions) was 22 +/- 2% and the mean recovery factor (the ratio of the number of surviving crypts using long interfraction intervals to that at zero time) was 11 +/- 2. The split-dose approach (Hendry 1979) using a 5 h interval has been used to estimate the number of clonogenic cells in large intestinal crypts. A range of single and paired doses between 7 Gy and 10.5 Gy were used. There were significant differences between the three regions of the large intestine, the caecum, mid-colon and rectum. The estimate of the number of clonogens also depended in a significant way on the dose of radiation used to make the estimate. At low doses large ...Continue Reading

References

Apr 1, 1977·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E Hamilton
May 1, 1975·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C S Potten, J H Hendry
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C S PottenJ V Moore
Sep 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J Huczkowski, K R Trott
Mar 1, 1983·European Journal of Cancer & Clinical Oncology·S L TuckerH D Thames
Feb 1, 1997·International Journal of Radiation Biology·W B CaiC S Potten

❮ Previous
Next ❯

Citations

Jan 24, 2009·Molecular & Cellular Proteomics : MCP·Baogang J XuRichard M Caprioli
Aug 7, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Robert G RamsayIvan Bertoncello
Jul 31, 2012·Journal of Radiation Research·Sanchita P GhoshK Sree Kumar
Oct 25, 2012·Health Physics·Catherine BoothThomas J MacVittie
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C S Potten
Oct 15, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·S RamalingamS T Magness
Aug 21, 2008·PloS One·Naomi D WillisChristopher J Hutchison
Feb 12, 2004·Cell Proliferation·M Brittan, N A Wright
Jul 22, 2008·Journal of Anatomy·Naomi D WillisRobert G Wilson
Dec 17, 2008·International Journal of Cancer. Journal International Du Cancer·Peter ChuRobert J Peach
Feb 23, 2008·Cellular & Molecular Biology Letters·Włodzimierz Korohoda, Anna Wilk
Dec 27, 2011·International Journal of Radiation Oncology, Biology, Physics·Ricardo M C GândaraChristopher S Potten
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Emma MarshmanChristopher S Potten
Feb 26, 2000·Carcinogenesis·S P BachC S Potten
Jul 13, 2007·Stem Cell Reviews·Tzung-Hai Yen, Nicholas A Wright
Oct 1, 2009·Cell Proliferation·C S PottenN A Wright
Jun 6, 2009·Virchows Archiv : an International Journal of Pathology·Stuart A C McDonaldMalcolm R Alison
May 18, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Catherine Legraverend, Philippe Jay
Jul 22, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Cecilia BullGunnar Steineck
Aug 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Qi-Ming PeiYa Jia
Apr 16, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Qi-ming PeiYa Jia
Jun 25, 1998·Experimental Cell Research·K MartinC S Potten
Feb 1, 2003·Differentiation; Research in Biological Diversity·Christopher S PottenHideyuki Okano
Jan 27, 2009·Gastroenterology·Nathan J Susnow, David M Hockenbery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.