The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of PTSD Re-Experiencing Symptoms

The Journal of Neuropsychiatry and Clinical Neurosciences
Carly K PetersonApostolos P Georgopoulos

Abstract

Apolipoprotien E (ApoE) is involved in critical neural functions and is associated with various neuropsychiatric disorders. ApoE exists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with posttraumatic stress disorder (PTSD) or subthreshold PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on PTSD symptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of ApoE in the brain.

Citations

Apr 15, 2015·Experimental Brain Research·Vassilios ChristopoulosApostolos P Georgopoulos
Dec 1, 2014·Psychiatry Research·Lisa M JamesApostolos P Georgopoulos
Mar 17, 2017·Experimental Brain Research·Lisa M JamesApostolos P Georgopoulos

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