The number of deformed joints as a surrogate measure of damage in rheumatoid arthritis

Arthritis and Rheumatism
Carlos H OrcesA Escalante

Abstract

To evaluate the reliability and validity of the number of deformed joints (NDJ) as a surrogate measure of joint damage in rheumatoid arthritis (RA). We tested interrater reliability and validity in determining the NDJ as a surrogate for joint damage in consecutive patients with RA. We rated each of 48 joints as normal or abnormal in terms of alignment and range of motion, and expressed the results as the total number of deformed joints. We compared the NDJ with the severity of damage on a plain radiograph of the hands, scored using Sharp's technique, as the gold standard measure of joint damage. We also compared the correlation between the NDJ and radiographic joint damage, on the one hand, and disease duration, performance-based measures of physical function, and the self-reported level of disability. The interrater reliability of the NDJ was excellent, with an intraclass correlation among four examiners of 0.94. To assess validity of the NDJ, we studied 273 RA patients from 5 clinical settings. Their average NDJ was 14 (range 0-43), and their average Sharp's score for joint space narrowing and erosions combined was 106 (range 4-309). The NDJ and the total Sharp's score were highly correlated (r = 0.83). Both measures were cor...Continue Reading

References

Apr 1, 1986·Arthritis and Rheumatism·Y S SherrerJ F Fries
Aug 1, 1966·Psychological Reports·J J Bartko
Apr 1, 1994·Arthritis and Rheumatism·H A Fuchs, T Pincus
Oct 29, 1998·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·A Escalante
Aug 14, 1999·Arthritis and Rheumatism·A Escalante, I del Rincón

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Citations

Jun 25, 2005·Rheumatology International·Raymond A H M SwinkelsCornelia H M van den Ende
Feb 9, 2007·Rheumatology International·Bedriye Mermerci BaşkanKürşat Ozoran
Oct 17, 2007·Rheumatology International·Murat BirtaneNurettin Tastekin
May 26, 2005·Clinical Rheumatology·Ismail BejiaNaceur Bergaoui
Jul 24, 2004·Annals of the Rheumatic Diseases·I del RincónA Escalante
Mar 17, 2005·BMC Musculoskeletal Disorders·Agustín EscalanteInmaculada del Rincón
Jul 1, 2004·Arthritis Research & Therapy·Agustín EscalanteInmaculada del Rincón
Jun 20, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Anne Barton, Sally John
Sep 18, 2003·Arthritis and Rheumatism·Gregorio Navarro-CanoAgustín Escalante
Dec 14, 2004·Arthritis and Rheumatism·Inmaculada del RincónAgustín Escalante
Nov 14, 2006·Atherosclerosis·Inmaculada Del RincónAgustín Escalante
Jun 10, 2004·Arthritis and Rheumatism·Agustín EscalanteJohn E Cornell
Feb 10, 2011·Arthritis and Rheumatism·Matthew R EvansInmaculada del Rincón
Feb 8, 2014·Arthritis & Rheumatology·Inmaculada del RincónAgustín Escalante
Dec 18, 2013·Arthritis Care & Research·Emily MolinaAgustin Escalante
May 23, 2014·Annals of the Rheumatic Diseases·Inmaculada Del RincónAgustín Escalante
May 25, 2005·Hypertension·Mary J RomanJane E Salmon
Jan 17, 2007·Clinical Orthopaedics and Related Research·Murray Baron, Russell Steele
Apr 3, 2008·Arthritis and Rheumatism·José F RoldánInmaculada del Rincón
Aug 6, 2005·Arthritis and Rheumatism·Ismail BejiaNaceur Bergaoui
Oct 29, 2005·Arthritis and Rheumatism·Inmaculada del RincónAgustín Escalante
May 24, 2017·BMC Musculoskeletal Disorders·Lijuan ZhangZhifeng Gu
Oct 7, 2015·BMC Musculoskeletal Disorders·Emily MolinaAgustin Escalante

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