Abstract
Deep intracerebral hematoma (ICH) is frequently associated with microbleed (MB) arising from degenerated MB. Increased numbers of MB are correlated with increased age, and we examined a possible relationship between MB number and ICH onset in younger patients. Excluding patients with ICH and a history of ICH, we examined the number of MB and other risk factors in 195 patients with deep ICH (97 male, 98 female) consecutively admitted to our hospital. The patients were equally divided into 3 subgroups according to age (groups A, B, and C). Odds ratios were estimated from logistic regression analyses. The number (percentage) of MB in group A (< or =60 years old, n = 64) 5.0 +/- 9.6 (65.6%) was less than group B (61-69 years old, n = 63) 6.6 +/- 9.1 (79.4%) or group C (> or =70 years old, n = 68) 6.0 +/- 7.0 (86.8%). Multivariate analyses demonstrated that MB greater than or equal to 3 was significantly associated with higher age in group A versus B (odds ratio: 2.3; 95% confidence interval: 1.01-5.3; P = .046) and in group A versus C (odds ratio: 2.6; 95% confidence interval: 1.1-6.2; P =.030). Our findings suggest that risk factors for the development of ICH may differ with age, and younger patients with deep ICH have fewer MB.
References
Jul 1, 1997·Diabetes Care
Jun 25, 1998·Neuroradiology·C D GoodP Wilkins
Sep 28, 1998·Annals of Neurology·V I KwaJ Stam
Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·A TanakaS Takebayashi
Dec 3, 1999·Stroke; a Journal of Cerebral Circulation·W I Rosenblum
Feb 9, 2000·Neuroradiology·J M Wardlaw, P F Statham
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·G RoobF Fazekas
Jan 10, 2002·Stroke; a Journal of Cerebral Circulation·Martin DichgansTarek A Yousry
Dec 7, 2002·Stroke; a Journal of Cerebral Circulation·Seung-Hoon LeeJae-Kyu Roh
Apr 26, 2003·Stroke; a Journal of Cerebral Circulation·Paula Jerrard-DunneHugh S Markus
May 2, 2003·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Toshio ImaizumiJun Niwa
Jul 5, 2003·Stroke; a Journal of Cerebral Circulation·M J AriesenA Algra
Jul 2, 2004·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Toshio ImaizumiJun Niwa
Dec 16, 2004·Journal of Neurosurgery·Toshio ImaizumiJun Niwa
Mar 5, 2005·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Toshio ImaizumiJun Niwa
Aug 6, 2005·Stroke; a Journal of Cerebral Circulation·Edward FeldmannRalph I Horwitz
Citations
Jan 26, 2010·Neurologia Medico-chirurgica·Kouichi MisakiJun-ichiro Hamada
Oct 16, 2015·Journal of Stroke·Eun-Jae LeeSteven Warach
Mar 31, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Toshio ImaizumiTatsufumi Nomura
Apr 18, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yan Wu, Tao Chen
Jul 3, 2013·The Tohoku Journal of Experimental Medicine·Jia YinXiao-Jia Liu
Jan 8, 2014·Journal of Stroke·Beom Joon Kim, Seung-Hoon Lee
Sep 24, 2019·Clinical and Experimental Hypertension : CHE·Lingchun LyuWei Mao
Mar 23, 2017·Frontiers in Aging Neuroscience·Kang YangYi Fu