The number of nucleoli in benign and malignant thyroid lesions: a useful diagnostic sign in cytological preparations

Cytopathology : Official Journal of the British Society for Clinical Cytology
R MontironiY Collan

Abstract

The slides of fine needle aspiration cytology specimens from 99 cases of cold thyroid nodules with known histology were reviewed and the number of nucleoli per nucleus counted and correlated with the different histopathological groups. Significant differences were observed between benign and malignant thyroid lesions in the number of nucleoli in the cytological material. Lower values were present in nodular goitres and follicular adenomas compared to carcinomas. In benign lesions the majority of nuclei contained one nucleolus and nuclei with two, three or more nucleoli were less frequent than in follicular, papillary, medullary and anaplastic carcinomas. Only one case of follicular adenoma had cells containing three or more nucleoli compared to more than half the cases of follicular carcinoma.

References

Jan 1, 1992·Cytopathology : Official Journal of the British Society for Clinical Cytology·R MontironiR Alberti
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·K Christov
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Citations

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·R MontironiR Alberti
May 1, 1992·Journal of Clinical Pathology·L Godinho-MatosA Kurtz
Jan 1, 1992·Cytopathology : Official Journal of the British Society for Clinical Cytology·R MontironiR Alberti
Aug 9, 2001·International Journal of Surgical Pathology·Lisa A. Cerilli, Mark R. Wick
Feb 17, 2018·Cancer Cell International·Feng ChenXin Ni

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