PMID: 9007576Jan 1, 1997Paper

The number of primary auditory afferents in the rat

Hearing Research
R D Hall, J L Massengill

Abstract

Published estimates of the number of primary auditory afferents in the rat differ by as much as 30%. We undertook to determine if the widely varying estimates were related to methodological differences, especially the difference between counting cells in Rosenthal's canal and fibers in the cochlear nerve. Type I ganglion cells and myelinated cochlear nerve fibers in the same ears were counted in Long-Evans and Sprague-Dawley strains. Type II spiral ganglion cells were also counted. In each strain the numbers of myelinated fibers and type I ganglion cells were essentially the same. Means for the Long-Evans were 18,036 fibers and 17,749 cells. Means for Sprague-Dawleys were higher: 19,444 fibers and 19,229 cells. The mean number of type II ganglion cells was also greater in Sprague-Dawley than in Long-Evans rats: 1,388 and 1,170, respectively. Cell and fiber counts from the two ears of the same animal differed on average by only 1%. The number of auditory afferents did not change with age over the range (2-10 months) studied here. Several methodological differences have probably contributed to the varying estimates of type I primary auditory afferents, but the discrepancies are not inherent in counts of fibers and spiral ganglion...Continue Reading

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Citations

Aug 29, 2003·Journal of the Association for Research in Otolaryngology : JARO·H LangR A Schmiedt
Mar 29, 2001·Neurotoxicology and Teratology·R LatayeP Bonnet
May 13, 2004·PLoS Biology·Gordon M Shepherd
May 3, 2011·Hearing Research·Bryony A NayagamDavid K Ryugo
May 28, 2011·Hearing Research·Pierre CampoCécile Parietti-Winkler

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